7 Results for "

PTTG1

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "PTTG1" in MCE Product Catalog:

Art. -Nr.: HY-N8146
CAS. Nr.: 53729-52-5
Bruceantinol is a quassinoid that can be isolated from Brucea javanica, inhibits pepper mottle virus (PepMoV) in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol has potent anti-leukemic activity. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC50 = 2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc. Bruceantinol binds with CDK2/4/6 to facilitate protein degradation through proteasome pathway. Bruceantinol can dose- and time-dependently reduces the cell growth, impede cell proliferation, disrupts the cell cycle, and induces necrosis in MCF-7 cells and apoptosis in MDA-MB-231 cells [1] .
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Art. -Nr.: HY-RS11456
Forschungsgebiete:  

Others

PTTG1 Human Pre-designed siRNA Set A contains three designed siRNAs for PTTG1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Art. -Nr.: HY-RS19029
Forschungsgebiete:  

Others

Pttg1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pttg1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Art. -Nr.: HY-RS25518
Forschungsgebiete:  

Others

Pttg1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pttg1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Art. -Nr.: HY-10424A
CAS. Nr.: 1253645-38-3
Synonyms: PHA-848125 maleate
Target:  

Ser/Thr Kinase

Forschungsgebiete:  

Cancer

Milciclib (PHA-848125) maleate is a cyclin-dependent kinase inhibitor that impairs melanoma cell growth and modulates gene expression involved in cell cycle regulation. Milciclib maleate has been shown to significantly affect the expression of various genes, including down-regulating PTTG1, contributing to its antiproliferative activity. Milciclib maleate enhances sensitivity to treatment in p53 mutated melanoma cells when combined with PTTG1 silencing.
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Art. -Nr.: HY-P82172
Synonyms: PTTG1; EAP1; PTTG; TUTR1; Securin; Esp1-associated protein; Pituitary tumor-transforming gene 1 protein; Tumor-transforming protein 1; hPTTG

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, FC

Reactivity:  

Human

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Art. -Nr.: HY-P82172A
Synonyms: PTTG1; EAP1; PTTG; TUTR1; Securin; Esp1-associated protein; Pituitary tumor-transforming gene 1 protein; Tumor-transforming protein 1; hPTTG

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, FC

Reactivity:  

Human

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