1 Result for "

Paxilline

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "Paxilline" in MCE Product Catalog:

11
Paxilline
Paxilline
0 Images
11 Cited Publications
Cat. No.: HY-N6778
CAS No.: 57186-25-1
Category:  

Alkaloids other families Microorganisms Neurological Disease Terpenoids Diterpenoids Plants Disease Research Fields Indole Alkaloids

Target:  

Potassium Channel Calcium Channel Reactive Oxygen Species (ROS)

Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca 2+-stimulated ATPase (SERCA), with IC50 values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity .
loading...
    loading...
View All Sizes
Assay Types