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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
Pyrazine derivatives
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "Pyrazine derivatives" in MCE Product Catalog:
Cat. No.: HY-W013040
CAS No.: 290-37-9
Synonyms: 1,4-Diazine
Target:
Research Areas:
Cardiovascular Disease Infection Inflammation/Immunology Cancer
Pyrazine (1,4-Diazine) is an aromatic nitrogen-containing heterocyclic compound with two nitrogen atoms, and is well known for its electron-deficient property. Pyrazine serves as a key pharmacophore in a variety of drugs, and also acts as the core skeleton of derivatives with anticancer, antimycobacterial, antithrombotic and anti-inflammatory activities .
Cat. No.: HY-W013040S
CAS No.: 1758-62-9
Synonyms: 1,4-Diazine-d4
Cat. No.: HY-W716669
CAS No.: 952-54-5
Target:
Research Areas:
Morinamide is an antibacterial agent, antitubercular agent and Pyrazine (HY-W013040) derivative. Morinamide can be used in the research of tuberculosis .
Cat. No.: HY-178448
Target:
EGFR JAK Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Cannabinoid Receptor Glutathione Peroxidase Caspase
Research Areas:
EGFR-IN-178 is an orally active EGFR mutant inhibitor, exhibits highly selective inhibitory activity against mutants of the EGFR enzyme, including Del19 (IC50 = 3.4 nM), L858R/T790 M (IC50 = 2.9 nM), and Del19/T790 M (IC50 = 2.5 nM). EGFR-IN-178 has good activity against JAK2 (IC50 = 55.6 nM) and JAK3 (IC50 = 46.1 nM) kinases. EGFR-IN-178 can increase cellular lipid oxide MDA, meanwhile decrease GSH content, causing ferroptosis in cancer cells. EGFR-IN-178 promotes apoptosis by increasing cleaved caspase-3 expression. EGFR-IN-178 can inhibit the phosphorylation of EGFR protein and decrease the active form p-JAK2 for JAK2, induce an increase in intracellular ROS. EGFR-IN-178 can be used for the study of non-small cell lung cancer (NSCLC) .
Cat. No.: HY-135078
CAS No.: 17460-13-8
Synonyms: NSC 270912
Target:
Research Areas:
2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry. Pyrazines, including 2,5-deoxyfructosazine, can be produced either by pyrolytic decomposition of natural compounds or by the reaction of sugars with alcoholic ammonia. 2,5-Deoxyfructosazine is also formed by the breakdown of D-glucosamine at neutral pH. Like glucosamine, 2,5-deoxyfructosazine has DNA strand breakage activity and strongly inhibits IL-2 production by Jurkat cells stimulated with phytohemagglutinin (IC50=~1.25 mM).
Cat. No.: HY-I0102
CAS No.: 402958-95-6
Target:
Research Areas:
Cat. No.: HY-I0115
CAS No.: 402958-96-7
Target:
Research Areas:
Cat. No.: HY-Z7429
CAS No.: 34876-35-2
Target:
3-Hydroxy-4-methyl-2(5H)-thiophenone (compound 18) is a pyrazine derivative and the major acidic degradation product of Cephalexin (HY-B0200) .
Cat. No.: HY-W777675
CAS No.: 1246815-27-9
Synonyms: NSC 270912-13C4
Cat. No.: HY-W041533
CAS No.: 34413-35-9
Target:
Research Areas:
5,6,7,8-Tetrahydroquinoxaline is a synthetic pyrazine derivative that also serves as a flavor enhancer for feed and food .
Cat. No.: HY-W985000
CAS No.: 163181-57-5
Target:
Cat. No.: HY-184376
CAS No.: 2095562-44-8
Antiparasitic agent-43 is a pyrazine derivative and a Plasmodium falciparum inhibitor with in vitro and in vivo antimalarial activity. It inhibits the growth of P. falciparum in vitro and can be used in research related to malaria .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
