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  4. Pyrazine

Pyrazine is an aromatic nitrogen-containing heterocyclic compound with two nitrogen atoms, and is well known for its electron-deficient property. Pyrazine serves as a key pharmacophore in a variety of drugs, and also acts as the core skeleton of derivatives with anticancer, antimycobacterial, antithrombotic and anti-inflammatory activities.

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Pyrazine

Pyrazine Chemical Structure

CAS No. : 290-37-9

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Pyrazine Related Antibodies

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Description

Pyrazine is an aromatic nitrogen-containing heterocyclic compound with two nitrogen atoms, and is well known for its electron-deficient property. Pyrazine serves as a key pharmacophore in a variety of drugs, and also acts as the core skeleton of derivatives with anticancer, antimycobacterial, antithrombotic and anti-inflammatory activities[1].

In Vitro

Pyrazine (sodamide; 30% H2O2/CH3COOH; 70-80 °C for H2O2/CH3COOH reaction) undergoes Chichibabin reaction with sodamide to form 2-aminopyrazine, and reacts with 30% H2O2/CH3COOH at 70-80 °C to form mono and dioxide products[1].
Pyrazine (300 °C for catalytic dehydrogenation) can be synthesized via catalytic dehydrogenation of ethanolamine (with optimal yield at 300 °C using copper catalyst) or via double condensation of a 1,2-dicarbonyl compound with equimolar 1,2-diamine followed by oxidation[1].
Pyrazine is a monobasic compound with a pKa of 0.65, protonated at N-1, and only undergoes N,N-diprotonation in very strong acidic media[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pyrazine Related Antibodies
Molecular Weight

80.09

Formula

C4H4N2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C1=NC=CN=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (1248.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 12.4860 mL 62.4298 mL 124.8595 mL
5 mM 2.4972 mL 12.4860 mL 24.9719 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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Purity & Documentation

Purity: 99.97%

SDS (466 KB)

COA (257 KB) HNMR (114 KB) GC (233 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 12.4860 mL 62.4298 mL 124.8595 mL 312.1488 mL
5 mM 2.4972 mL 12.4860 mL 24.9719 mL 62.4298 mL
10 mM 1.2486 mL 6.2430 mL 12.4860 mL 31.2149 mL
15 mM 0.8324 mL 4.1620 mL 8.3240 mL 20.8099 mL
20 mM 0.6243 mL 3.1215 mL 6.2430 mL 15.6074 mL
25 mM 0.4994 mL 2.4972 mL 4.9944 mL 12.4860 mL
30 mM 0.4162 mL 2.0810 mL 4.1620 mL 10.4050 mL
40 mM 0.3121 mL 1.5607 mL 3.1215 mL 7.8037 mL
50 mM 0.2497 mL 1.2486 mL 2.4972 mL 6.2430 mL
60 mM 0.2081 mL 1.0405 mL 2.0810 mL 5.2025 mL
80 mM 0.1561 mL 0.7804 mL 1.5607 mL 3.9019 mL
100 mM 0.1249 mL 0.6243 mL 1.2486 mL 3.1215 mL
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Pyrazine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

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