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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
Ritonavir
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "Ritonavir" in MCE Product Catalog:
33
Target:
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.61 μM. Ritonavir (ABT 538) can penetrate the blood brain barrier (BBB) .
13
13 Cited Publications
Synonyms: ABT-450; Veruprevir
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Research Areas:
Paritaprevir (ABT-450) is a potent, orally active and antiviral non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively. Paritaprevir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.31 μM. Paritaprevir is metabolized primarily by cytochrome P450 (CYP) 3A. The plasma concentration and half-life of Paritaprevir can be enhanced by Ritonavir (a CYP450 inhibitor) .
1
1 Cited Publications
Cat. No.: HY-90001R
CAS No.: 155213-67-5
Synonyms: ABT 538 (Standard); RTV (Standard)
Ritonavir (Standard) is the analytical standard of Ritonavir. This product is intended for research and analytical applications. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.61 μM.
Cat. No.: HY-90001S
CAS No.: 1616968-73-0
Synonyms: ABT 538-d6; RTV-d6
Cat. No.: HY-G0009
CAS No.: 176655-55-3
Synonyms: Desthiazolylmethyloxycarbonyl Ritonavir
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Research Areas:
Ritonavir metabolite is a metabolite of Ritonavir, which is a HIV protease inhibitor.
Cat. No.: HY-150574
CAS No.: 2771297-34-6
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Research Areas:
CYP3A4-IN-1 (compound 5a) is a potent cytochrome P450 3A4 (CYP3A4) inhibitor with an IC50 value of 0.085 µM .
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Research Areas:
Hydroxy ritonavir is a metabolite of Ritonavir. Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS .
Cat. No.: HY-150580
CAS No.: 2562383-94-0
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Research Areas:
CYP3A4-IN-2 is a specific inhibitor of cytochrome P450 3A4 (CYP3A4) with the IC50 value of 0.055 μM. CYP3A4-IN-2 is a ritonavir analogue with increased hydrophobicity of the R2 side group and stronger inhibitory effect compared to ritonavir. CYP3A4-IN-2 can be used as an antiviral agent and immunosuppressants .
Cat. No.: HY-136986
CAS No.: 256328-82-2
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Research Areas:
Desthiazolylmethyl ritonavir is a base-catalyzed degradation product of the HIV protease inhibitor Ritonavir (HY-90001).
Cat. No.: HY-90001S2
Synonyms: ABT 538-d8; RTV-d8
Cat. No.: HY-90001S3
CAS No.: 1217720-20-1
Synonyms: rel-ABT 538-d6; rel-RTV-d6
Cat. No.: HY-W653853
CAS No.: 1217673-23-8
Synonyms: ABT 538-13C3; RTV-13C3
Cat. No.: HY-90001S1
CAS No.: 2937755-89-8
Synonyms: ABT 538-13C,d3; RTV-13C,d3
Cat. No.: HY-150581
CAS No.: 2562384-19-2
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Research Areas:
CYP3A4-IN-3 is a high-affinity specific inhibitor of cytochrome P450 3A4 (CYP3A4) with the IC50 value of 0.075 μM. CYP3A4-IN-3 is a ritonavir analogue, but with a simpler structure and twice the inhibitory effect of ritonavir. CYP3A4-IN-3 is used as an antiviral agent and immunosuppressant .
Cat. No.: HY-12594A
CAS No.: 1456607-71-8
Synonyms: ABT-450 dihydrate; Veruprevir dihydrate
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Research Areas:
Paritaprevir (ABT-450) dihydrate is a potent, orally active and antiviral non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively. Paritaprevir dihydrate is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.31 μM. Paritaprevir dihydrate is metabolized primarily by cytochrome P450 (CYP) 3A. The plasma concentration and half-life of Paritaprevir dihydrate can be enhanced by Ritonavir (a CYP450 inhibitor) .
Cat. No.: HY-12594R
CAS No.: 1216941-48-8
Synonyms: ABT-450 (Standard); Veruprevir (Standard)
Target:
Research Areas:
Paritaprevir (Standard) is the analytical standard of Paritaprevir. This product is intended for research and analytical applications. Paritaprevir (ABT-450) is a potent, orally active and antiviral non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively. Paritaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.31 μM. Paritaprevir is metabolized primarily by cytochrome P450 (CYP) 3A. The plasma concentration and half-life of Paritaprevir can be enhanced by Ritonavir (a CYP450 inhibitor) .
Cat. No.: HY-121057
CAS No.: 67739-71-3
Synonyms: 3-OH FNTZ
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Research Areas:
3-Hydroxyflunitrazepam (3-OH FNTZ) is the major metabolite of Flunitrazepam (FNTZ), generated via 3-hydroxylation by CYP3A4 (Km = 286 μM), and represents the dominant metabolic pathway (>80%) in liver microsomes. Its formation is significantly inhibited by CYP3A4 inhibitors such as Ketoconazole (HY-B0105) (IC50 = 0.11 μM) and Ritonavir (HY-90001) (IC50 = 0.041 μM), indicating a strong dependence on CYP3A4 activity and potential drug interactions .
Cat. No.: HY-W879508
CAS No.: 173026-17-0
Synonyms: BXT-51072
Research Areas:
ALT-2074 (BXT-51071) is an orally active catalytic analogue of glutathione peroxidase. ALT-2074 is an inhibitor of human CYP3A, with its IC50 value ranging from 2.0 to 2.6 μM. ALT-2074 shows only a weak inhibitory effect on CYP3A in vivo, suggesting that it may not significantly affect the metabolism of CYP3A substrate drugs. ALT-2074 can be used to study inflammatory diseases characterized by reactive oxygen species, such as acute coronary syndrome .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
