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Results for "

SRSF1

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Recombinant Proteins

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-117661
    SPHINX31
    10+ Cited Publications

    		 SRPK VEGFR Cardiovascular Disease Cancer
    SPHINX31 is a potent and selective SRPK1 inhibitor, with an IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1). SPHINX31 also decreases the mRNA expression of pro-angiogenic VEGF-A165a isoform. SPHINX31 can be used to research neovascular eye disease [1] .
    SPHINX31
  • HY-170935
    SRSF1-IN-1

    		SRPK PARP Caspase Apoptosis Autophagy Cancer
    SRSF1-IN-1 is a SRSF1 inhibitor. SRSF1-IN-1 inhibits SRSF1 expression, thereby modulating the splicing of Bcl-x pre-mRNA. SRSF1-IN-1 inhibits the proliferation of various cancer cells. SRSF1-IN-1 induces apoptosis in gastric cancer cells, reduces Bcl-xl expression, and upregulates cleaved PARP and caspase 3. SRSF1-IN-1 induces autophagy and promotes cell death. SRSF1-IN-1 exhibits anti-tumor activity in a mouse gastric cancer xenograft model. SRSF1-IN-1 can be used for the research of various cancers including liver cancer, gastric cancer, breast cancer, colon cancer, glioma, and melanoma [1].
    SRSF1-IN-1
  • HY-RS13790
    SRSF1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SRSF1 Human Pre-designed siRNA Set A contains three designed siRNAs for SRSF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SRSF1 Human Pre-designed siRNA Set A
    SRSF1 Human Pre-designed siRNA Set A
  • HY-RS23624
    Srsf1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Srsf1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Srsf1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Srsf1 Rat Pre-designed siRNA Set A
    Srsf1 Rat Pre-designed siRNA Set A
  • HY-RS17174
    Srsf1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Srsf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Srsf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Srsf1 Mouse Pre-designed siRNA Set A
    Srsf1 Mouse Pre-designed siRNA Set A
  • HY-125201
    Indazole 1

    		CDK Inflammation/Immunology
    Indazole 1 is a potent CDC2-like kinase 2 (CLK2) inhibitor (IC50=12.3 nM). Indazole 1 inhibits the phosphorylation of SR proteins (e.g., SRSF1, SRSF3) and modulates alternative splicing of Wnt signaling-related genes. Indazole 1 is promising for research of osteoarthritis [1].
    Indazole 1
  • HY-E70660
    CDK13/CycK Recombinant Human Active Protein Kinase

    		CDK Cancer
    CDK13/CycK Recombinant Human Active Protein Kinase is a RNA polymerase II C-terminal domain kinases. CDK13 interacts with the splicing factor SRSF1 and to regulate alternative splicing of HIV [1].
    CDK13/CycK Recombinant Human Active Protein Kinase
  • HY-183831
    GPS167

    		MDM-2/p53 PARP Caspase Apoptosis Cancer
    GPS167 is a CLK kinase inhibitor that potently and selectively inhibits recombinant human CLK1, CLK2 and CLK4. By inhibiting CLK-mediated phosphorylation of SRSF10, GPS167 upregulates the protein-binding ability of CLK1 and CLK4 with SRSF10, downregulates oncogenic BCLAF1-L and upregulates tumor-suppressive BCLAF1-S, regulates alternative splicing of genes such as MDM2 and MDM4, stabilizes p53 protein and induces DNA damage, ultimately triggering tumor cell apoptosis. GPS167 can block the epithelial-mesenchymal transition process of tumors, activate intracellular double-stranded RNA-mediated antiviral immune responses, and produce synergistic cytotoxicity when combined with microtubule-targeting drugs. GPS167 can be used in research related to various cancers including colorectal cancer [1] .
    GPS167

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