2252153-37-8
2252153-37-8
Chemical Structure
Indazole 1
- CAS. Nr.: 2252153-37-8
- Formula:C19H24N4O
- Molecular Weight:324.42
IUPAC Name: (S)-4-methyl-1-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)pentan-2-amine
InChIKey: CEDLXWRFEZCVEU-INIZCTEOSA-N
SMILES: CC(C)C[C@H](N)COC1=CC(C2=CC3=C(NN=C3C)C=C2)=CN=C1
Biological Activity: Indazole 1 is a potent CDC2-like kinase 2 (CLK2) inhibitor (IC50=12.3 nM). Indazole 1 inhibits the phosphorylation of SR proteins (e.g., SRSF1, SRSF3) and modulates alternative splicing of Wnt signaling-related genes. Indazole 1 is promising for research of osteoarthritis[1].
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Indazole 1 | Indazole 1 is a potent CDC2-like kinase 2 (CLK2) inhibitor (IC50=12.3 nM). Indazole 1 inhibits the phosphorylation of SR proteins (e.g., SRSF1, SRSF3) and modulates alternative splicing of Wnt signaling-related genes. Indazole 1 is promising for research of osteoarthritis. | |||||||||||||||||||||
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