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TMS1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Caspase (1) DNA Methyltransferase (1) Mitochondrial Metabolism (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

DNMT-IN-6	DNA Methyltransferase Apoptosis Caspase Mitochondrial Metabolism	Cancer
DNMT-IN-6 is a DNA methyltransferase inhibitor with activity against *DNMT1, DNMT3A, and DNMT3B. DNMT-IN-6 drives demethylation, and restores TMS1* tumor suppressor gene expression. DNMT-IN-6 induces apoptosis, causes G2/M phase arrest, disrupts mitochondrial integrity, and activates the intrinsic caspase cascade (3/7/9). DNMT-IN-6 inhibits tumor growth, and improves survival in xenograft models. DNMT-IN-6 can be used for the research of cancer, such as diffuse large B-cell lymphoma ^[1].

PYCARD Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PYCARD Human Pre-designed siRNA Set A contains three designed siRNAs for PYCARD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SERINC3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SERINC3 Human Pre-designed siRNA Set A contains three designed siRNAs for SERINC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pycard Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pycard Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pycard gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701308

	PYCARD Protein, Human (HEK293, His-Myc) 1 Publications Verification PYCARD; PYD And CARD Domain Containing; CARD5; ASC; Apoptosis-Associated Speck-Like Protein Containing A CARD; TMS-1; Caspase Recruitment Domain-Containing Protein 5; TMS1; PYD And CARD Domain-Containing Protein; TMS; HASC	Human	HEK293
	PYCARD proteins are key mediators of apoptosis and inflammation and promote caspase-mediated apoptosis, specifically involving caspase-8 and, in certain cells, caspase-9. It activates the mitochondrial apoptotic pathway, promoting caspase-8-dependent BID maturation and BAX-dependent apoptosis through caspase-9, -2, and -3. PYCARD Protein, Human (HEK293, His-Myc) is the recombinant human-derived PYCARD protein, expressed by HEK293 , with C-Myc, N-10*His labeled tag.

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Host:	Mouse (2) Rabbit (3)
Reactivity:	Human (4) Rat (2) Mouse (2)
Application:	IHC-P (3) ICC/IF (5) IP (1) IHC-F (1) WB (3) FC (3) ELISA (4)
Isotype:	IgG (3) IgG1 (2)
Conjugation:	Non-conjugated (5)
Clonality:	Polyclonal (1) Monoclonal (3) Recombinant (1)
Modification:	Unmodified (4)

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HY-P84876

	TMS1/ACS Antibody (YA4573) ASC; TMS; TMS1; CARD5; TMS-1	IHC-P, ICC/IF, FC, ELISA	Human
	TMS1/ACS Antibody (YA4573) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TMS1/ACS.

HY-P84876A

	TMS1/ACS Antibody (YA4573)(PBS only) ASC; TMS; TMS1; CARD5; TMS-1	IHC-P, ICC/IF, FC, ELISA	Human
	TMS1/ACS Antibody (YA4573) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TMS1/ACS.

HY-P80522

	TMS1/ACS Antibody (YA033) 1 Publications Verification PYCARD; ASC; CARD5; TMS1; Apoptosis-associated speck-like protein containing a CARD; hASC; Caspase recruitment domain-containing protein 5; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1	WB, ICC/IF, FC	Human
	TMS1/ACS Antibody (YA033) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TMS1/ACS.

HY-P86234

	TMS1/ACS Antibody (YA5926) PYCARD; ASC; CARD5; TMS1; Apoptosis-associated speck-like protein containing a CARD; hASC; Caspase recruitment domain-containing protein 5; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1	WB, ICC/IF, IP, ELISA	Mouse, Rat
	TMS1/ACS Antibody (YA5926) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TMS1/ACS.

HY-P80548

	TMS1/ACS Antibody 5 Publications Verification PYCARD; ASC; CARD5; TMS1; Apoptosis-associated speck-like protein containing a CARD; hASC; Caspase recruitment domain-containing protein 5; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	TMS1/ACS Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to TMS1/ACS.

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HY-RS11485

PYCARD Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PYCARD Human Pre-designed siRNA Set A contains three designed siRNAs for PYCARD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12692

SERINC3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SERINC3 Human Pre-designed siRNA Set A contains three designed siRNAs for SERINC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS19524

Pycard Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Pycard Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pycard gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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