3038316-36-5
Chemical Structure
DNMT-IN-6
- CAS No.: 3038316-36-5
- Formula:C19H18AsNO3S2
- Molecular Weight:447.40
InChIKey: YAPBQBMNMWPGHS-YCRREMRBSA-N
SMILES: O=C(NC1=CC=C(C=C1)[As]2SCCCS2)/C=C/C3=CC4=C(OCO4)C=C3
Biological Activity: DNMT-IN-6 is a DNA methyltransferase inhibitor with activity against DNMT1, DNMT3A, and DNMT3B. DNMT-IN-6 drives demethylation, and restores TMS1 tumor suppressor gene expression. DNMT-IN-6 induces apoptosis, causes G2/M phase arrest, disrupts mitochondrial integrity, and activates the intrinsic caspase cascade (3/7/9). DNMT-IN-6 inhibits tumor growth, and improves survival in xenograft models. DNMT-IN-6 can be used for the research of cancer, such as diffuse large B-cell lymphoma[1].
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DNMT-IN-6 | DNMT-IN-6 is a DNA methyltransferase inhibitor with activity against DNMT1, DNMT3A, and DNMT3B. DNMT-IN-6 drives demethylation, and restores TMS1 tumor suppressor gene expression. DNMT-IN-6 induces apoptosis, causes G2/M phase arrest, disrupts mitochondrial integrity, and activates the intrinsic caspase cascade (3/7/9). DNMT-IN-6 inhibits tumor growth, and improves survival in xenograft models. DNMT-IN-6 can be used for the research of cancer, such as diffuse large B-cell lymphoma. | |||||||||||||||||||||
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