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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
TROP-2 targeted ADC
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "TROP-2 targeted ADC" in MCE Product Catalog:
11
11 Publications Verification
Synonyms: IMMU-132
11
11 Publications Verification
Synonyms: IMMU-132 (solution)
9
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2 Cited Publications
Synonyms: DS-1062 (solution); Dato-DXd (solution)
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Datopotamab deruxtecan (DS-1062) is a TROP2-targeted antibody-drug conjugate (ADC) with human TROP2 Kd of 0.74 nmol/L. Datopotamab deruxtecan consists of the antibody Datopotamab (HY-P99843) and the toxic molecule-linker conjugate Deruxtecan (HY-13631E). Datopotamab deruxtecan binds TROP2, triggers internalization and lysosomal trafficking and releases DXd topoisomerase I inhibitor payload. Datopotamab deruxtecan disrupts DNA function, induces DNA damage, apoptosis, and bystander killing of tumor microenvironment cells. Datopotamab deruxtecan can be used in research related to triple-negative breast cancer, gastric cancer, and non-small cell lung cancer .
Cat. No.: HY-P991097
Synonyms: PM-8002; BNT-327
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Cat. No.: HY-P99045A
CAS No.: 1796566-95-4
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Cat. No.: HY-P992127
CAS No.: 3037073-23-4
Synonyms: BAT8008 Antibody; BAT0806
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Cat. No.: HY-P992518
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
