3 Results for "

Tabersonine

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Tabersonine" in MCE Product Catalog:

3
Tabersonine
Tabersonine
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3 Cited Publications
Cat. No.: HY-N1431
CAS No.: 4429-63-4
Category:  

Apocynaceae Alkaloids Plants Indole Alkaloids Catharanthus roseus (L.) G. Don

Target:  

NOD-like Receptor (NLR) Apoptosis Cytochrome P450 NF-κB PI3K Akt CDK Caspase Interleukin Related p38 MAPK

Tabersonine is a selective, orally active NLRP3 inhibitor. Tabersonine directly binds to the NACHT domain of NLRP3, inhibiting its ATPase activity and oligomerization, thereby blocking ASC spot formation and caspase-1 activation, and reducing the release of pro-inflammatory cytokines such as IL-1β. Tabersonine also inhibits K63-linked ubiquitination of TRAF6, blocking NF-κB, PI3K/Akt, and p38 MAPK signaling pathways. Tabersonine can inhibit inflammatory responses, induce apoptosis of liver cancer cells through mitochondrial pathways and death receptor pathways, reduce mitochondrial membrane potential, promote cytochrome c release, and activate caspase proteins. Tabersonine is mainly used in the study of NLRP3-driven inflammatory diseases (such as acute lung injury, sepsis, peritonitis) and tumors such as liver cancer .
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3
Tabersonine hydrochloride
Tabersonine hydrochloride
0 Images
3 Cited Publications
Cat. No.: HY-N1431A
CAS No.: 29479-00-3
Category:  

Apocynaceae Alkaloids Plants Indole Alkaloids Catharanthus roseus (L.) G. Don

Target:  

NOD-like Receptor (NLR) Apoptosis Cytochrome P450 NF-κB PI3K Akt CDK Caspase Interleukin Related p38 MAPK

Tabersonine hydrochloride is a selective, orally active NLRP3 inhibitor. Tabersonine hydrochloride directly binds to the NACHT domain of NLRP3, inhibiting its ATPase activity and oligomerization, thereby blocking ASC spot formation and caspase-1 activation, and reducing the release of pro-inflammatory cytokines such as IL-1β. Tabersonine hydrochloride also inhibits K63-linked ubiquitination of TRAF6, blocking NF-κB, PI3K/Akt, and p38 MAPK signaling pathways. Tabersonine hydrochloride can inhibit inflammatory responses, induce apoptosis of liver cancer cells through mitochondrial pathways and death receptor pathways, reduce mitochondrial membrane potential, promote cytochrome c release, and activate caspase proteins. Tabersonine hydrochloride is mainly used in the study of NLRP3-driven inflammatory diseases (such as acute lung injury, sepsis, peritonitis) and tumors such as liver cancer .
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3-Hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase
3-Hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase
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Cat. No.: HY-E71694
Target:  

Biochemical Assay Reagents

Research Areas:  

Others

3-Hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase (EC 2.1.1.99) involved in the biosynthesis of vindoline from tabersonine in the Madagascar periwinkleCatharanthus roseus.
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