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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
Tetrazole
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "Tetrazole" in MCE Product Catalog:
Cat. No.: HY-W054424
CAS No.: 1638767-25-5
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tert-Butyl (3-aminobicyclo[1.1.1]pentan-1-yl) carbamate is a pharmaceutical intermediate used in the synthesis of various active compounds, such as for the preparation of tetrazole-based eIF2B activators .
Cat. No.: HY-W004131
CAS No.: 4916-55-6
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3-Bromomethylpyridine hydrobromide is an intermediate that can be used for the preparation of 1,5-disubstituted tetrazole-based P2X7 antagonists .
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5-(M-Tolyl)tetrazole is a drug intermediate for synthesis of various active compounds.
Cat. No.: HY-W010517S
CAS No.: 345909-96-8
Cat. No.: HY-143335
CAS No.: 2901064-06-8
Antifungal agent 52 (compound 6c) is a tetrazole derivative. Antifungal agent 52 inhibits the synthesis of Ergosterol (HY-N0181). Antifungal agent 52 exhibit a significant antifungal activity against Candida albicans. Antifungal agent 52 affects C. albicans sessile cell membrane permeabilization .
Cat. No.: HY-153934
CAS No.: 873874-16-9
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Tetrazole-C15-(N-acetylsulfamoyl)butanoic acid (Ligand 1) improves the pharmacokinetic properties of therapeutic peptides and proteins through non-covalent binding with human serum albumin (HSA). Tetrazole-C15-(N-acetylsulfamoyl)butanoic acid can be used for synthesis of long-acting human growth hormone (HGH) analog somapacitan .
Cat. No.: HY-134953
CAS No.: 916923-10-9
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Mephetyl tetrazole is a potassium channel Kv1.5 blocker, with an IC50 of 330 nM. Mephetyl tetrazole can be used for the research of cancer .
Cat. No.: HY-174353
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CYP51-IN-22, the non-deuterated analog of CYP51-IN-23-d3 (HY-174353S), is a potent and broad-spectrum CYP51 inhibitor.CYP51-IN-22 inhibits Aspergillus fumigatum with a MIC80 of 1 μg/mL. CYP51-IN-22 can prevent fungal phase transformation and biofilm formation. CYP51-IN-22 exhibits anti-drug resistance activity and fungal activity, and shows excellent safety for cells and significant pharmacological activity in mice. CYP51-IN-22 can be used for the study of invasive fungal infections (IFIs) .
Cat. No.: HY-174353S
Cat. No.: HY-117742
CAS No.: 380382-38-7
DA-7867 is an antibacterial compound with activity against a wide range of bacteria, including drug-resistant bacteria. DA-7867 shows promising antibacterial activity against some clinically important pathogens, including drug-resistant bacteria. It is an amide analog of Tedizolid (HY-14855), reflecting the potential use of tetrazoles in the development of new antibacterial agents .
Cat. No.: HY-155152
CAS No.: 3052839-42-3
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P-gp/BCRP-IN-2 (compound 15) is an oxadiazole derivative and a dual inhibitor of the ABC transporter P-glycoprotein (IC50: 1.6 nM) and BCRP (IC50: 600 nM). P-gp/BCRP-IN-2 also enhances the anti-proliferative effects of Doxorubicin (HY-15142A) in drug-resistant human adenocarcinoma colon cancer cell lines HT29/DX and MDCK-MDR1 cells .
Cat. No.: HY-149376
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Tubulin inhibitor 38 (compound 14) is a tetrazole-based Tubulin inhibitor with antiproliferative potencies. Tubulin inhibitor 38 (100 nM，24 h) mediates mitotic arrest，blocks cell cycle at G2/M phase and induces apoptosis. Tubulin inhibitor 38 exhibits high cytotoxicity with high selectivity index among HeLa，MCF7，and U87 MG cells .
Cat. No.: HY-W010517R
CAS No.: 13183-79-4
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1-Methyl-1H-tetrazole-5-thiol (Standard) is the analytical standard of 1-Methyl-1H-tetrazole-5-thiol. This product is intended for research and analytical applications.
Cat. No.: HY-W743814
Cat. No.: HY-124255R
CAS No.: 120568-11-8
Synonyms: Losartan impurity 4 (Standard)
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Losartan impurity E (Standard) is the analytical standard of Losartan impurity E. This product is intended for research and analytical applications.
Cat. No.: HY-182024
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SARS-CoV-2 3CLpro-IN-36 is a SARS-CoV-2 3CLpro inhibitor and antiviral agent with a human sub-micromolar IC50 against SARS-CoV-2 3CLpro.SARS-CoV-2 3CLpro-IN-36 forms a covalent bond with catalytic Cys145 of SARS-CoV-2 3CLpro; its tetrazole core occupies the S1 pocket and interacts with His163, while its chloroacetamide carbonyl forms hydrogen bonds with the backbone amides of Gly143 and Ser144 in the oxyanion hole.SARS-CoV-2 3CLpro-IN-36 reduces SARS-CoV-2 replication in infected cells.SARS-CoV-2 3CLpro-IN-36 can be used for the research of SARS-CoV-2 infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
