1 Result for "

Thienodolin

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Thienodolin" in MCE Product Catalog:

Thienodolin
Thienodolin
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Cat. No.: HY-N16376
CAS No.: 149127-27-5
Synonyms: MJ 286A
Category:  

Alkaloids Microorganisms Pyridine Alkaloids

Target:  

NF-κB STAT

Thienodolin (MJ 286A) is an alkaloid that has been found in S. albogriseolus. Thienodolin inhibits nitric oxide production in LPS (HY-D1056)-stimulated RAW 264.7 murine macrophage cells with an IC50 value of 17.2 μM. Thienodolin suppresses iNOS, blocks the degradation of IκBα, attenuates NF-κB p65 accumulation in the nucleus, and reduces the phosphorylation level of STAT1 at Tyr701. Thienodolin can be used for the study of inflammation .
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