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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
UGT1A1 microsomes
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "UGT1A1 microsomes" in MCE Product Catalog:
Cat. No.: HY-160250
CAS No.: 2097024-37-6
Target:
Research Areas:
UGT1A1-IN-1 is a UGT1A1 inhibitor and fluorescent probe (Ex=370 nm, Em=520 nm), with an IC50 of 1.33 μM and a Ki of 5.02 μM. UGT1A1-IN-1 is selectively glucuronidated by UGT1A1 at the bilirubin homologous binding site, and its PET effect is blocked along with this reaction, triggering fluorescence changes. UGT1A1-IN-1 can serve as a substitute for bilirubin to detect UGT1A1 activity and perform high-throughput screening of UGT1A1 modulators .
Cat. No.: HY-N4267
CAS No.: 13060-14-5
Cat. No.: HY-E72105
Human UGT1A1 is a uridine diphosphate glucuronosyltransferase (UGT). Human UGT1A1 mediates the metabolism of active compounds by conjugating glucuronic acid to toxic or lipophilic compounds, converting them into water-soluble waste products that can be safely eliminated from the human body via bile or urine .
Cat. No.: HY-122163
CAS No.: 1149750-69-5
Research Areas:
MK-3901 is a selective P2X3 receptor antagonist with an IC50 of 24 nM. MK-3901 inhibits UGT1A1 (with an IC50 of 1 μM) and CYP2C9 (with an IC50 of 5.7 μM). MK-3901 activates PXR. MK-3901 induces hyperbilirubinemia. MK-3901 can be used for the research of inflammatory pain .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
