1149750-69-5
Chemical Structure
MK-3901
- CAS No.: 1149750-69-5
- Formula:C28H24FN5O2
- Molecular Weight:481.53
IUPAC Name: N-((R)-1-(5-fluoropyridin-2-yl)ethyl)-3-(5-methylpyridin-2-yl)-5-((S)-5-(pyridin-2-yl)-4,5-dihydroisoxazol-3-yl)benzamide
InChIKey: SUXRXYKUAHNUAX-CLYVBNDRSA-N
SMILES: C(N[C@H](C)C1=CC=C(F)C=N1)(=O)C2=CC(=CC(=C2)C3=CC=C(C)C=N3)C=4C[C@H](ON4)C5=CC=CC=N5
Biological Activity: MK-3901 is a selective P2X3 receptor antagonist with an IC50 of 24 nM. MK-3901 inhibits UGT1A1 (with an IC50 of 1 μM) and CYP2C9 (with an IC50 of 5.7 μM). MK-3901 activates PXR. MK-3901 induces hyperbilirubinemia. MK-3901 can be used for the research of inflammatory pain[1].
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MK-3901 | MK-3901 is a selective P2X3 receptor antagonist with an IC50 of 24 nM. MK-3901 inhibits UGT1A1 (with an IC50 of 1 μM) and CYP2C9 (with an IC50 of 5.7 μM). MK-3901 activates PXR. MK-3901 induces hyperbilirubinemia. MK-3901 can be used for the research of inflammatory pain. | |||||||||||||||||||||
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Keywords
