2097024-37-6
Chemical Structure
UGT1A1-IN-1
- CAS No.: 2097024-37-6
- Formula:C22H19NO3
- Molecular Weight:345.39
InChIKey: JRXIYIQGSHSLMX-UHFFFAOYSA-N
SMILES: O=C1C2=CC=CC3=C2C(C(N1CCCC)=O)=CC=C3C4=CC=C(O)C=C4
Biological Activity: UGT1A1-IN-1 is a UGT1A1 inhibitor and fluorescent probe (Ex=370 nm, Em=520 nm), with an IC50 of 1.33 μM and a Ki of 5.02 μM. UGT1A1-IN-1 is selectively glucuronidated by UGT1A1 at the bilirubin homologous binding site, and its PET effect is blocked along with this reaction, triggering fluorescence changes. UGT1A1-IN-1 can serve as a substitute for bilirubin to detect UGT1A1 activity and perform high-throughput screening of UGT1A1 modulators[1].
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UGT1A1-IN-1 | 99.27% | UGT1A1-IN-1 is a UGT1A1 inhibitor and fluorescent probe (Ex=370 nm, Em=520 nm), with an IC50 of 1.33 μM and a Ki of 5.02 μM. UGT1A1-IN-1 is selectively glucuronidated by UGT1A1 at the bilirubin homologous binding site, and its PET effect is blocked along with this reaction, triggering fluorescence changes. UGT1A1-IN-1 can serve as a substitute for bilirubin to detect UGT1A1 activity and perform high-throughput screening of UGT1A1 modulators. | ||||||||||||||||||||
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Keywords
