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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
Wi-38 normal human fibroblasts
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "Wi-38 normal human fibroblasts" in MCE Product Catalog:
Cat. No.: HY-157404
CAS No.: 2918764-16-4
Pim-1/2 kinase inhibitor 2 (compound 5b) is a competitive PIM-1 and PIM-2 kinase inhibitor with IC50s of 1.31 μM and 0.67 μM, respectively. Pim-1/2 kinase inhibitor 2 shows in-vitro low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent in-vitro anticancer activity against myeloid leukaemia (NFS-60), liver (HepG-2), prostate (PC-3), and colon (Caco-2) cancer cell lines .
Cat. No.: HY-N11128
CAS No.: 19941-91-4
Target:
Cat. No.: HY-187512
Research Areas:
DprE1-IN-16 is a DprE1 inhibitor against Mycobacterium tuberculosis, with an IC50 value of 11.74 μM. DprE1-IN-16 binds within the catalytic site of DprE1, forming hydrogen bonds, π-cation interactions, π-sulfur interactions and hydrophobic contacts with Lys134, Gly117, Tyr415, Lys418, Cys387 and Val365. DprE1-IN-16 can be used in the research of bacterial and fungal infections as well as tuberculosis .
Cat. No.: HY-184792
Research Areas:
CA/PRAK-IN-1 is a dual inhibitor of carbonic anhydrase (Carbonic Anhydrase) and PRAK, with a Ki of 20.1 nM against hCA IX and 16.4 nM against hCA XII. CA/PRAK-IN-1 exhibits inhibitory activity against YES1 kinase, BTK, and MAP4K3. CA/PRAK-IN-1 induces G0/G1 phase arrest of the cancer cell cycle, inhibits DNA synthesis, disrupts hypoxia-driven survival pathways, promotes cell death, and shows broad-spectrum cytotoxicity against tumor cells. CA/PRAK-IN-1 can be used in research on various cancers including leukemia, colon cancer, melanoma, and renal cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
