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Results for "

Zinc-binding

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-160822
    AGG-523

    PF-5212371

    		 ADAMTS MMP Inflammation/Immunology
    AGG-523 (PF-5212371) is an orally active, reversible, non-hydroxamate, zinc-binding selective inhibitor of ADAMTS4 and ADAMTS5 with IC50 of <0.03 and 0.04 μM. AGG-523 also inhibits MMP-2, -8, 12 activity AGG-523 attenuates release of aggrecanase-generated ARG-aggrecan fragments into synovial fluid, reduces surgery-induced ARG-aggrecan release in rat joint models, and inhibits aggrecanase activity to slow cartilage degradation. AGG-523 can be used for the research of osteoarthritis .
    AGG-523
  • HY-174313
    Antibacterial agent 284

    		Bacterial Toll-like Receptor (TLR) Collagen Infection Inflammation/Immunology
    Antibacterial agent 284 (Compound 7) is an Antibacterial agent. Antibacterial agent 284 has a zinc-binding structure and potent inhibitory activity against Legionella pneumophila metalloprotease ProA (IC50: 0.96 μM) with zinc-binding structure. Antibacterial agent 284 significantly inactivates the cleavage of collagen IV and flagellin (ProA substrates) and reduces immune evasion from the TLR5-NF-κB pathway and PMN-mediated inflammation in human lung tissue explants. Antibacterial agent 284 is promising for Legionnaires' disease research .
    Antibacterial agent 284
  • HY-174591
    Human LHX3 mRNA

    		mRNA Neurological Disease
    Human LHX3 mRNA encodes the human LIM homeobox 3 (LHX3) protein, a member of a large proteins family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. LHX3 is a transcription factor that is required for pituitary development and motor neuron specification.
    Human LHX3 mRNA
  • HY-176241
    DC-174

    		Others Cardiovascular Disease
    DC-174 is an orally active inhibitor of snake venom metalloproteinases (SVMP) with a broad spectrum of inhibitory activity against a variety of snake venom SVMPs. DC-174 acts directly on the active site of SVMPs via zinc-binding groups, inhibiting their enzymatic activity and procoagulant toxicity. DC-174 can significantly prolong the survival time of mice attacked by snake venom. DC-174 can be used in the study of first aid for snake bites .
    DC-174
  • HY-171776
    OPB-3206

    		MMP Cancer
    OPB-3206 is a selective matrix metalloproteinase (MMP) inhibitor. OPB-3206 inhibits interstitial collagenase, gelatinase A (MMP-2), gelatinase B (MMP-9) and stromelysin with IC50 values of 7×10 -7 M, 5×10 -6 M, 5×10 -7 M and 2×10 -6 M, respectively. OPB-3206 reversibly binds to the zinc-binding region of MMPs, preventing the activation of MMP-9 and reducing extracellular matrix degradation to inhibit tumor lung metastasis. OPB-3206 is promising for research of lung metastasis of osteosarcoma .
    OPB-3206
  • HY-117093
    H8-A5

    		HDAC Cancer
    H8-A5 is a novel human histone deacetylase 8 (HDAC8) inhibitor. A highly specific ZBG-based pharmacophore model was developed by incorporating a custom zinc-binding group (ZBG) feature. Pharmacophore-based virtual screening identified three novel HDAC8 inhibitors with low micromolar IC50 values (1.8-1.9 μM). Further studies showed that H8-A5 was more selective for HDAC8 than HDAC1/4 and exhibited antiproliferative activity in MDA-MB-231 cancer cells. Molecular docking and molecular dynamics studies showed that H8-A5 could bind to HDAC8, providing a good starting point for the development of HDAC8 inhibitors for cancer treatment.
    H8-A5
  • HY-165381
    ZMC2

    		MDM-2/p53 Reactive Oxygen Species (ROS) Cancer
    ZMC2 is a thiosemicarbazone-class metal ion chelator and zinc ionophore with a human mutant p53 R175H binding Ka of 27.4 nM.ZMC2 binds Fe, Cu, Mn, Zn, and other transition metals.ZMC2 facilitates zinc transport across membranes.ZMC2 restores zinc binding to zinc-deficient p53 mutants, restoring wild-type structure and function, including site-specific DNA binding.ZMC2 generates reactive oxygen species (ROS).ZMC2 can be used for the research of cancer .
    ZMC2
  • HY-114065
    MMP3-IN-4

    		MMP Cancer
    MMP3-IN-4 is a MMP-3 inhibitor with a pIC50 value of 6.301. MMP3-IN-4 can be used in cancer research .
    MMP3-IN-4

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