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Results for "

cap-dependent translation

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

3

Biochemical Assay Reagents

6

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14427
    4E1RCat
    3 Publications Verification

    		 Eukaryotic Initiation Factor (eIF) Autophagy Cancer
    4E1RCat is an inhibitor of cap-dependent translation, and inhibits eIF4E:eIF4GI interaction, with an IC50 an of ～4 μM.
    4E1RCat
  • HY-21586B
    7-Methyl-guanosine-5'-triphosphate sodium

    m7GTP sodium

    		 Nucleoside Antimetabolite/Analog Others
    7-Methyl-guanosine-5'-triphosphate (m7GTP) sodium is a guanosine 5'-phosphate. 7-Methyl-guanosine-5'-triphosphate sodium phosphorothioate analog is a potent cap-dependent translation inhibitor .
    7-Methyl-guanosine-5'-triphosphate sodium
  • HY-145969
    β-S-ARCA

    3'-O-Me-m7G(5')ppp(5')G

    		 DNA/RNA Synthesis Eukaryotic Initiation Factor (eIF) Cancer
    β-S-ARCA (3'-O-Me-m7G(5')ppp(5')G) is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. β-S-ARCA binds eIF4E via electrostatic interactions between its β-sulfur atom and positively charged Arg and Lys residues in the protein binding site. β-S-ARCA prevents the decapping by Dcp2, increases the mRNA half-life, enhances cap-dependent translation, and increases protein expression in cells. β-S-ARCA has been applied in researching experimental mRNA-based anticancer vaccines .
    β-S-ARCA
  • HY-145969A
    β-S-ARCA triammonium

    3’-O-Me-m7G(5')ppp(5')G triammonium

    		 DNA/RNA Synthesis Eukaryotic Initiation Factor (eIF) Cancer
    β-S-ARCA (3'-O-Me-m7G(5')ppp(5')G) triammonium is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. β-S-ARCA triammonium binds eIF4E via electrostatic interactions between its β-sulfur atom and positively charged Arg and Lys residues in the protein binding site. β-S-ARCA triammonium prevents the decapping by Dcp2, increases the mRNA half-life, enhances cap-dependent translation, and increases protein expression in cells. β-S-ARCA triammonium has been applied in researching experimental mRNA-based anticancer vaccines .
    β-S-ARCA triammonium
  • HY-139098
    7-Methyl-diguanosine triphosphate

    m7Gp3G

    		 DNA/RNA Synthesis Others
    7-Methyl-diguanosine triphosphate (m7Gp3G) is an mRNA cap structure analog that inhibits in vitro protein synthesis by binding to the translation initiation complex. 7-Methyl-diguanosine triphosphate binds to eIF4E, promotes cap-dependent translation initiation, stabilizes mRNA, and acts as a translation enhancer. 7-Methyl-diguanosine triphosphate can be used to prepare synthetic capped RNA transcripts for studies related to mRNA translation, splicing, turnover, and intracellular transport .
    7-Methyl-diguanosine triphosphate
  • HY-148664
    eIF4E-IN-4

    		Eukaryotic Initiation Factor (eIF) Cancer
    eIF4E-IN-4 (Compound 33) is a selective inhibitor of eukaryotic initiation factor 4E (eIF4E) with biochemical activity value of 95 nM. eIF4E-IN-4 inhibits cap-dependent mRNA translation with an IC50 value of 2.5 μM. eIF4E-IN-4 can be used for breast cancer, colon cancer, and head and neck cancer study .
    eIF4E-IN-4
  • HY-155676
    eIF4E-IN-5

    		Eukaryotic Initiation Factor (eIF) Cancer
    eIF4E-IN-5 (Compound 6n) is a eIF4E cell-permeable inhibitor. eIF4E-IN-5 can bind to capped mRNA to inhibit cap-dependent translation .
    eIF4E-IN-5
  • HY-21586
    7-Methyl-guanosine-5'-triphosphate disodium

    m7GTP disodium

    		 Nucleoside Antimetabolite/Analog Metabolic Disease
    7-Methyl-guanosine-5'-triphosphate (m7GTP) disodium is a guanosine 5'-phosphate. 7-Methyl-guanosine-5'-triphosphate disodium phosphorothioate analog is a potent cap-dependent translation inhibitor .
    7-Methyl-guanosine-5'-triphosphate disodium
  • HY-21586A
    m7GTP

    7-Methyl-guanosine-5'-triphosphate

    		 Nucleoside Antimetabolite/Analog Metabolic Disease
    7-Methyl-guanosine-5'-triphosphate (m7GTP) is a guanosine 5'-phosphate. 7-Methyl-guanosine-5'-triphosphate phosphorothioate analog is a potent cap-dependent translation inhibitor .
    m7GTP
  • HY-139098A
    7-Methyl-diguanosine triphosphate ammonium

    m7Gp3G ammonium

    		 DNA/RNA Synthesis Others
    7-Methyl-diguanosine triphosphate (m7Gp3G) ammonium is an mRNA cap structure analog that inhibits in vitro protein synthesis by binding to the translation initiation complex. 7-Methyl-diguanosine triphosphate ammonium binds to eIF4E, promotes cap-dependent translation initiation, stabilizes mRNA, and acts as a translation enhancer. 7-Methyl-diguanosine triphosphate ammonium can be used to prepare synthetic capped RNA transcripts for studies related to mRNA translation, splicing, turnover, and intracellular transport .
    7-Methyl-diguanosine triphosphate ammonium
  • HY-178672A
    ARCA triammonium solution (100 mM)

    Anti-Reverse cap analog triammonium solution (100 mM); m2 7,3′O GpppG triammonium solution (100 mM)

    		 DNA/RNA Synthesis Cancer
    ARCA (Anti-Reverse cap analog) triammonium solution (100 mM) is a 5′-cap analogue. ARCA triammonium solution (100 mM) caps mRNA. ARCA triammonium solution (100 mM) can be used in protein expression studies .
    ARCA triammonium solution (100 mM)

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