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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
cap-dependent translation
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "cap-dependent translation" in MCE Product Catalog:
4
4 Cited Publications
Research Areas:
4E1RCat is an inhibitor of cap-dependent translation, and inhibits eIF4E:eIF4GI interaction, with an IC50 an of ～4 μM.
Cat. No.: HY-145969
CAS No.: 1093268-63-3
Synonyms: 3'-O-Me-m7G(5')ppp(5')G
Research Areas:
β-S-ARCA (3'-O-Me-m7G(5')ppp(5')G) is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. β-S-ARCA binds eIF4E via electrostatic interactions between its β-sulfur atom and positively charged Arg and Lys residues in the protein binding site. β-S-ARCA prevents the decapping by Dcp2, increases the mRNA half-life, enhances cap-dependent translation, and increases protein expression in cells. β-S-ARCA has been applied in researching experimental mRNA-based anticancer vaccines .
Cat. No.: HY-145969A
Purity: 99.48%
Synonyms: 3’-O-Me-m7G(5')ppp(5')G triammonium
Research Areas:
β-S-ARCA (3'-O-Me-m7G(5')ppp(5')G) triammonium is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. β-S-ARCA triammonium binds eIF4E via electrostatic interactions between its β-sulfur atom and positively charged Arg and Lys residues in the protein binding site. β-S-ARCA triammonium prevents the decapping by Dcp2, increases the mRNA half-life, enhances cap-dependent translation, and increases protein expression in cells. β-S-ARCA triammonium has been applied in researching experimental mRNA-based anticancer vaccines .
Cat. No.: HY-139098
CAS No.: 62828-64-2
Synonyms: m7Gp3G
Cat. No.: HY-148664
CAS No.: 1373822-39-9
Research Areas:
eIF4E-IN-4 (Compound 33) is a selective inhibitor of eukaryotic initiation factor 4E (eIF4E) with biochemical
activity value of 95 nM. eIF4E-IN-4 inhibits cap-dependent mRNA translation with an IC50 value of 2.5 μM. eIF4E-IN-4 can be used for breast cancer, colon cancer, and head and neck cancer study .
Cat. No.: HY-155676
Research Areas:
eIF4E-IN-5 (Compound 6n) is a eIF4E cell-permeable inhibitor. eIF4E-IN-5 can bind to capped mRNA to inhibit cap-dependent translation .
Cat. No.: HY-21586
CAS No.: 104809-18-9
Synonyms: m7GTP disodium
Target:
Research Areas:
7-Methyl-guanosine-5'-triphosphate (m7GTP) disodium is a guanosine 5'-phosphate. 7-Methyl-guanosine-5'-triphosphate disodium phosphorothioate analog is a potent cap-dependent translation inhibitor .
Cat. No.: HY-21586A
CAS No.: 26554-26-7
Synonyms: 7-Methyl-guanosine-5'-triphosphate
Target:
Research Areas:
7-Methyl-guanosine-5'-triphosphate (m7GTP) is a guanosine 5'-phosphate. 7-Methyl-guanosine-5'-triphosphate phosphorothioate analog is a potent cap-dependent translation inhibitor .
Cat. No.: HY-139098A
CAS No.: 75252-12-9
Synonyms: m7Gp3G ammonium
Cat. No.: HY-173172
CAS No.: 3076503-34-6
Research Areas:
MG-002 is an orally active eIF4A1 and eIF4A2 inhibitor with a human eIF4A1 IC50 of 43 nM. MG-002 prevents competent ribosome recruitment to mRNA, inhibits cap-dependent mRNA translation, and engages eIF4A2 via the same RNA clamping mechanism to inhibit mRNA translation. MG-002 induces G2/M cell cycle delay, induces apoptosis, suppresses synthesis of c-MYC and cyclin D1, and shows minimal overt toxicity in mice. MG-002 inhibits primary triple-negative breast cancer tumor growth, attenuates metastatic spread, and enhances anti-neoplastic activity of Doxorubicin (HY-15142A) in pre-clinical models .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
