75252-12-9
Chemical Structure
7-Methyl-diguanosine triphosphate ammonium solution (100 mM)
Synonym(s): m7Gp3G ammonium
- CAS No.: 75252-12-9
- Formula:C21H35N12O18P3
- Molecular Weight:836.49
InChIKey: RMORGOQTGFXHBX-DQNSRKNCSA-N
SMILES: O=P(O)(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2NC(N)=NC3=O)O1)OP(OP(OC[C@H]4O[C@@H](N5C(NC(N)=N6)=C([N+](C)=C5)C6=O)[C@H](O)[C@@H]4O)([O-])=O)(O)=O.N.N
Biological Activity:
7-Methyl-diguanosine triphosphate (m7Gp3G) ammonium is an mRNA cap structure analog that inhibits in vitro protein synthesis by binding to the translation initiation complex. 7-Methyl-diguanosine triphosphate ammonium binds to eIF4E, promotes cap-dependent translation initiation, stabilizes mRNA, and acts as a translation enhancer. 7-Methyl-diguanosine triphosphate ammonium can be used to prepare synthetic capped RNA transcripts for studies related to mRNA translation, splicing, turnover, and intracellular transport[1][2].
The product specifications provided below indicate the total amount only; they do not represent the actual content of 7-Methyl-diguanosine triphosphate ammonium.
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7-Methyl-diguanosine triphosphate ammonium solution (100 mM) | 98.83% | 7-Methyl-diguanosine triphosphate (m7Gp3G) ammonium is an mRNA cap structure analog that inhibits in vitro protein synthesis by binding to the translation initiation complex. 7-Methyl-diguanosine triphosphate ammonium binds to eIF4E, promotes cap-dependent translation initiation, stabilizes mRNA, and acts as a translation enhancer. 7-Methyl-diguanosine triphosphate ammonium can be used to prepare synthetic capped RNA transcripts for studies related to mRNA translation, splicing, turnover, and intracellular transport. The product specifications provided below indicate the total amount only; they do not represent the actual content of 7-Methyl-diguanosine triphosphate ammonium. |
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References
- [1]. Grudzien E, et al. Differential inhibition of mRNA degradation pathways by novel cap analogs. J Biol Chem. 2006;281(4):1857-1867. [Content Brief]
- [2]. Grudzien-Nogalska E, et al. Synthesis of anti-reverse cap analogs (ARCAs) and their applications in mRNA translation and stability. Methods Enzymol. 2007;431:203-227. [Content Brief]
