5 Results for "

human NPFF2 receptor

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "human NPFF2 receptor" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P1428
CAS No.: 311309-25-8
Research Areas:  

Endocrinology

RFRP-1(human) is a gonadotropin-inhibitory hormone (GnIH) homolog. RFRP-1(human) targets human gonadotropin-releasing hormone (GnRH) neurons and gonadotropes and potently inhibits gonadotropin. RFRP-1(human) is a potent Neuropeptide FF (NPFF) receptor agonist with EC50s of 0.0011 nM and 29 nM for NPFF2 and NPFF1, respectively .
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Cat. No.: HY-P1248
CAS No.: 99566-27-5
Synonyms: NPFF
Neuropeptide FF (NPFF), an octapeptide belonging to the RF-amide family of peptides, is a NPFF1 and NPFF2 receptors agonist with Ki values of 2.82 nM and 0.21 nM, respectively. Neuropeptide FF induces abstinence syndrome, exerts antiopioid and analgesic effects, releases via calcium-dependent mechanisms from rat spinal cord, regulates memory, autonomic function, and neuroendocrine function, modulates pain and opioid antinociception, reduces food intake, stimulates water intake, alters cardiovascular parameters, and shows differential activity in hypothalamic paraventricular nucleus neurons. Neuropeptide FF is present in mammalian central nervous system and periphery, with NPFF-immunoreactivity increases in rat cerebrospinal fluid during opiate tolerance, and its NPFF gene and NPFF-R2 gene are up-regulated in rat spinal cord and dorsal root ganglia during peripheral inflammation. Neuropeptide FF can be used for the research of opioid tolerance, morphine-induced analgesia, abstinence syndrome, pain, hypertension, nociception, inflammatory pain, and neuropathic pain .
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Cat. No.: HY-P1428A
Research Areas:  

Cardiovascular Disease

RFRP-1(human) TFA is a potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats.
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Cat. No.: HY-P11811A
Research Areas:  

Metabolic Disease

GUB10194 acetate is a fully potent and selective GPR10 agonist with an EC50 of 15 nM. GUB10194 acetate does not significantly affect body weight or food intake .
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Cat. No.: HY-P11811
Research Areas:  

Metabolic Disease

GUB10194 is a fully potent and selective GPR10 agonist with an EC50 of 15 nM. GUB10194 does not significantly affect body weight or food intake .
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