99566-27-5
Chemical Structure
Neuropeptide FF
Synonym(s): NPFF
- CAS No.: 99566-27-5
- Formula:C54H76N14O10
- Molecular Weight:1081.27
IUPAC Name: (S)-2-((S)-1-(L-phenylalanyl-L-leucyl-L-phenylalanyl-L-glutaminyl)pyrrolidine-2-carboxamido)-N1-((S)-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)pentanediamide
InChIKey: HWYCFZUSOBOBIN-AQJXLSMYSA-N
SMILES: N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCC(N)=O)C(N3[C@@H](CCC3)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)=O
Biological Activity: Neuropeptide FF (NPFF), an octapeptide belonging to the RF-amide family of peptides, is a NPFF1 and NPFF2 receptors agonist with Ki values of 2.82 nM and 0.21 nM, respectively. Neuropeptide FF induces abstinence syndrome, exerts antiopioid and analgesic effects, releases via calcium-dependent mechanisms from rat spinal cord, regulates memory, autonomic function, and neuroendocrine function, modulates pain and opioid antinociception, reduces food intake, stimulates water intake, alters cardiovascular parameters, and shows differential activity in hypothalamic paraventricular nucleus neurons. Neuropeptide FF is present in mammalian central nervous system and periphery, with NPFF-immunoreactivity increases in rat cerebrospinal fluid during opiate tolerance, and its NPFF gene and NPFF-R2 gene are up-regulated in rat spinal cord and dorsal root ganglia during peripheral inflammation. Neuropeptide FF can be used for the research of opioid tolerance, morphine-induced analgesia, abstinence syndrome, pain, hypertension, nociception, inflammatory pain, and neuropathic pain[1][2][3][4][5][6][7].
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Neuropeptide FF | 99.35% | Neuropeptide FF (NPFF), an octapeptide belonging to the RF-amide family of peptides, is a NPFF1 and NPFF2 receptors agonist with Ki values of 2.82 nM and 0.21 nM, respectively. Neuropeptide FF induces abstinence syndrome, exerts antiopioid and analgesic effects, releases via calcium-dependent mechanisms from rat spinal cord, regulates memory, autonomic function, and neuroendocrine function, modulates pain and opioid antinociception, reduces food intake, stimulates water intake, alters cardiovascular parameters, and shows differential activity in hypothalamic paraventricular nucleus neurons. Neuropeptide FF is present in mammalian central nervous system and periphery, with NPFF-immunoreactivity increases in rat cerebrospinal fluid during opiate tolerance, and its NPFF gene and NPFF-R2 gene are up-regulated in rat spinal cord and dorsal root ganglia during peripheral inflammation. Neuropeptide FF can be used for the research of opioid tolerance, morphine-induced analgesia, abstinence syndrome, pain, hypertension, nociception, inflammatory pain, and neuropathic pain. | ||||||||||||||||||||
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- [1]. Mollereau C, et al. Pharmacological characterization of human NPFF(1) and NPFF(2) receptors expressed in CHO cells by using NPY Y(1) receptor antagonists. Eur J Pharmacol. 2002 Sep 20;451(3):245-56. [Content Brief]
- [2]. Panula P, et al. Neuropeptide FF, a mammalian neuropeptide with multiple functions. Prog Neurobiol. 1996;48(4-5):461-487. [Content Brief]
- [3]. Jhamandas JH, et al. Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation. Front Endocrinol (Lausanne). 2013;4:8. Published 2013 Feb 7. [Content Brief]
- [4]. Yang HY, et al. Modulatory role of neuropeptide FF system in nociception and opiate analgesia. Neuropeptides. 2008;42(1):1-18. [Content Brief]
- [5]. Sun YL, et al. Neuropeptide FF activates ERK and NF kappa B signal pathways in differentiated SH-SY5Y cells. Peptides. 2012;38(1):110-117. [Content Brief]
- [6]. Murase T, et al. Neuropeptide FF reduces food intake in rats. Peptides. 1996;17(2):353-354. [Content Brief]
- [7]. Ankö ML, et al. Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK-N-MC neuroblastoma cell line. J Neurochem. 2006;96(2):573-584. [Content Brief]
Keywords
