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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
hydrophobic modification
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "hydrophobic modification" in MCE Product Catalog:
Cat. No.: HY-Y1353
CAS No.: 24424-99-5
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Di-tert-butyl dicarbonate (tBOC) is a covalent modification agent for hydroxyl groups (-OH) on the chitosan molecular chain. Di-tert-butyl dicarbonate selectively modifies chitosan and stabilizes the material structure through hydrophobic encapsulation. Di-tert-butyl dicarbonate reacts with the -OH groups of chitosan to form a hydrophobic layer, and in conjunction with triethylamine (TEA), removes trifluoroacetic acid (TFA) salts produced during the electrospinning process, preserving the nanofiber structure and high porosity of the membrane, and improving the material's cytocompatibility and mineralization-promoting ability. Di-tert-butyl dicarbonate can be used in research in the field of guided bone regeneration (GBR) .
Cat. No.: HY-N4031
CAS No.: 82375-29-9
Synonyms: Perfluorotripropylamine; FTPA; Tris(perfluoropropyl)amine
Cat. No.: HY-W142140
CAS No.: 2566-32-7
Synonyms: N-Methylvaline
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Cat. No.: HY-W142140A
Synonyms: N-Methylvaline hydrochloride
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N-Methyl-DL-valine (N-Methylvaline) hydrochloride is a valine derivant, is metabolized to cysteine, alanine, tyrosine, tryptophan, citric acid, and succinic acid in the sprout. N-Methyl-DL-valine hydrochloride involves in the modification of monomethyl auristatin F (MMAF), an anti-tubulin agent, makes it hydrophobic functionalization and increases cell permeability .
Cat. No.: HY-108299R
CAS No.: 338-83-0
Synonyms: Perfluorotripropylamine (Standard); FTPA (Standard); Tris(perfluoropropyl)amine (Standard)
Cat. No.: HY-185907
CAS No.: 1772522-17-4
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5'-Octyltocopherol C8 CE Phosphoramidite is a tocopherol-based phosphoramidite modification monomer for solid-phase oligonucleotide synthesis, which can introduce an octyltocopherol modification group with a C8 spacer arm at the 5'-end of oligonucleotides. 5'-Octyltocopherol C8 CE Phosphoramidite can be used to prepare DNA or RNA with hydrophobic tocopherol terminal modifications. 5'-Octyltocopherol C8 CE Phosphoramidite is applicable to studies related to oligonucleotide chemical synthesis, nucleic acid hydrophobic modification, and nucleic acid conjugate construction.
Cat. No.: HY-185910
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Palmitamido-C7 CE-Phosphoramidite is a long-chain esterified phosphoramidite monomer used for solid-phase oligonucleotide synthesis. Palmitamido-C7 CE-Phosphoramidite is formed by linking palmitamido to the active end of 2-cyanoethyl phosphoramidite via a C7 alkyl spacer arm. Palmitamido-C7 CE-Phosphoramidite can be used as a building block for nucleic acid chemical modification to synthesize ester-coupled oligonucleotides.
Cat. No.: HY-W1061406
CAS No.: 161029-24-9
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Spacer-C2 Phosphoramidite is a C2 spacer phosphoramidite modifier for oligonucleotide synthesis that introduces a hydrophobic two-carbon spacer internally or at the 5′ end of an oligonucleotide. Spacer-C2 Phosphoramidite increases the distance between an oligonucleotide and a modifier, thereby reducing interactions between the modifier and the oligonucleotide sequence, and can be used for oligonucleotide modification and labeling research.
Cat. No.: HY-185404
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DSPE-PEG8-OH is a monodisperse lipid-polyethylene glycol conjugate featuring a hydrophobic 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) anchor, an 8-unit discrete (PEG8) spacer, and a terminal hydroxyl (-OH) group. DSPE-PEG8-OH is primarily used in liposome formulation, nanoparticle surface modification, and targeted drug delivery systems.
Cat. No.: HY-L942
1,631 compounds
Unlike highly conserved orthosteric sites, allosteric sites exhibit low conservation, high hydrophobicity, weak polarity, confined geometry, and dynamic cryptic properties. Rather than rigid keyhole-like cavities, they typically appear as flexible grooves, subunit interface clefts, or shallow depressions formed by protein conformational changes.
Based on the dynamic, hydrophobic, and elongated nature of allosteric pockets, MCE has carried out targeted fragment modification and screening under strict physicochemical criteria: MW 120–280 Da, HBD ≤ 2, HBA ≤ 3, PSA 30–80 Ų, rotatable bonds ≤ 2, cLogP 1–3.5. High 3D diversity was further ensured by PMI analysis, yielding fragments with excellent shape complementarity to allosteric pockets.
This library contains 1,800 structurally diverse, drug-like fragments, this library supports allosteric drug development and pocket optimization. It significantly improves screening hit rates and enables efficient, precise early-stage R&D of allosteric drugs.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
