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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
intra-ventricular
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "intra-ventricular" in MCE Product Catalog:
3
3 Cited Publications
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
VP3.15 dihydrobromide is a highly potent, orally bioavailable, and CNS-penetrant PDE7-GSK3 dual inhibitor, with IC50 values of 1.59 μM and 0.88 μM against PDE7 and GSK3, respectively . VP3.15 dihydrobromide elevates intracellular cAMP levels, suppresses immune responses, enhances remyelination, limits excessive tau phosphorylation, and alleviates neuroinflammation and neuronal loss. VP3.15 dihydrobromide promotes oligodendrocyte precursor cell differentiation, improves in vivo remyelination, inhibits autoimmune encephalomyelitis, and mitigates germinal matrix-intraventricular hemorrhage-related brain injury, cerebral atrophy, ventricular enlargement, and cognitive impairment. VP3.15 dihydrobromide can be used in research related to multiple sclerosis and germinal matrix-intraventricular hemorrhage .
Synonyms: MJ9067
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Encainide (MJ9067) is an antiarrhythmic agent with class IC activity. Encainide blocks voltage-dependent potassium channels. Encainide has the potential for life-threatening ventricular arrhythmias, symptomatic ventricular arrhythmias and supraventricular arrhythmias research .
Cat. No.: HY-130325
CAS No.: 73477-53-9
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α-Guanidinoglutaric acid is a guanidino compound first found in cobaltinduced epileptogenic focus tissue in the cerebral cortex of cats. α-Guanidinoglutaric acid induces epileptic seizures in rats after intraventricular administration .
Cat. No.: HY-102092
CAS No.: 142375-60-8
Synonyms: PD 147953
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FR139317 (PD 147953) is a selective ETA receptor antagonist. FR139317 inhibits cerebral activation by intraventricular endothelin-1 in conscious rats. FR139317 also ameliorates cerebral vasospasm in dogs .
Cat. No.: HY-12531
CAS No.: 66794-74-9
Synonyms: MJ9067 hydrochloride
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Encainide (MJ9067) hydrochloride is an antiarrhythmic agent with class IC activity. Encainide hydrochloride blocks voltage-dependent potassium channels. Encainide hydrochloride has the potential for life-threatening ventricular arrhythmias, symptomatic ventricular arrhythmias and supraventricular arrhythmias research .
Cat. No.: HY-P991755
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Research Areas:
Cat. No.: HY-115839
CAS No.: 47719-70-0
Synonyms: Tachmalcor free base
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Research Areas:
Detajmium (Tachmalcor free base) is a Na?-channel blocker with activity to inhibit ventricular conduction and refractoriness. Detajmium (0.3μM) prolongs intraventricular conduction time comparable to propafenone (0.3μM) during sinus rhythm, but the time constant for reaching steady state during rapid ventricular pacing is significantly longer for Detajmium, indicating a unique temporal profile for its heart rate-dependent effects.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
