142375-60-8
142375-60-8
Chemical Structure
FR139317
Synonym(s): PD 147953
- CAS No.: 142375-60-8
- Formula:C33H44N6O5
- Molecular Weight:604.74
IUPAC Name: (R)-2-((R)-2-((S)-2-(azepane-1-carboxamido)-4-methylpentanamido)-3-(1-methyl-1H-indol-3-yl)propanamido)-3-(pyridin-2-yl)propanoic acid
InChIKey: LIOKMIQQPDDTNO-UPRLRBBYSA-N
SMILES: O=C(O)[C@@H](CC1=NC=CC=C1)NC([C@@H](CC2=CN(C)C3=CC=CC=C23)NC([C@H](CC(C)C)NC(N4CCCCCC4)=O)=O)=O
Biological Activity: FR139317 (PD 147953) is a selective ETA receptor antagonist. FR139317 inhibits cerebral activation by intraventricular endothelin-1 in conscious rats. FR139317 also ameliorates cerebral vasospasm in dogs[1][2].
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FR139317 | FR139317 (PD 147953) is a selective ETA receptor antagonist. FR139317 inhibits cerebral activation by intraventricular endothelin-1 in conscious rats. FR139317 also ameliorates cerebral vasospasm in dogs. | |||||||||||||||||||||
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References
- [1]. Gross PM, et al. FR139317, a specific ETA-receptor antagonist, inhibits cerebral activation by intraventricular endothelin-1 in conscious rats. Neuropharmacology. 1994 Oct;33(10):1155-66. [Content Brief]
- [2]. Nirei H, et al. An endothelin ETA receptor antagonist, FR139317, ameliorates cerebral vasospasm in dogs. Life Sci. 1993;52(23):1869-74. [Content Brief]
