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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
intravitreally
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "intravitreally" in MCE Product Catalog:
Art. -Nr.: HY-P99830
CAS. Nr.: 1227158-72-6
Synonyms: KH902
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Art. -Nr.: HY-16387
CAS. Nr.: 854514-88-8
PF-00337210 is a potent and selective inhibitor of VEGFRs, designed for treating age-related macular degeneration via intravitreal injection. The formulation strategy focused on developing an ophthalmic solution that would precipitate upon injection into the vitreous, ensuring sustained drug delivery. Challenges included maintaining low dosing volumes, selecting safe excipients for intravitreal use, and addressing the drug's unique physicochemical properties. The final formulation, an isotonic solution in a citrate-buffered vehicle with NaCl, demonstrated stability, potency, and recovery through intravitreal dosing syringes. It formed a depot upon injection into vitreous humor, representing a novel nonpolymeric in situ-forming depot formulation for intravitreal drug delivery .
Art. -Nr.: HY-P991886
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Art. -Nr.: HY-P991030
CAS. Nr.: 2839527-15-8
Synonyms: OG-2072
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Art. -Nr.: HY-P992142
CAS. Nr.: 3050549-24-8
Synonyms: ANX-007
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
