3 Results for "

kirenol

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "kirenol" in MCE Product Catalog:

1
Kirenol
Kirenol
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1 Cited Publications
Cat. No.: HY-N0559
CAS No.: 52659-56-0
Category:  

Terpenoids Bituminaria morisiana (Pignatti & Metlesics) Greuter Diterpenoids Plants Compositae

Target:  

Casein Kinase Apoptosis AMPK Akt NF-κB TGF-beta/Smad

Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a Kd value of 5.47 μM against the target CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53 and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the CK2/AKT and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis .
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Kirenol (Standard)
Kirenol (Standard)
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Cat. No.: HY-N0559R
CAS No.: 52659-56-0
Category:  

Terpenoids Bituminaria morisiana (Pignatti & Metlesics) Greuter Diterpenoids Plants Compositae

Target:  

Reference Standards Casein Kinase Apoptosis AMPK Akt NF-κB TGF-beta/Smad

Kirenol (Standard) is the analytical standard of Kirenol (HY-N0559). This product is intended for research and analytical applications. Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a Kd value of 5.47 μM against the target CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53 and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the CK2/AKT and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis.
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(6-Rac)-Kirenol
(6-Rac)-Kirenol
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Cat. No.: HY-N0559A
CAS No.: 1622876-96-3
Category:  

Terpenoids Diterpenoids Plants Compositae Tephrosia candida DC.

Target:  

Elastase

(6-Rac)-Kirenol is an ent-pimarane-type diterpenoid. (6-Rac)-Kirenol inhibits the production of superoxide anions in activated human neutrophils. (6-Rac)-Kirenol inhibits the release of elastase from activated human neutrophils .
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