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non-degradable

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Biochemical Assay Reagents (8) Drug Isomer (1) Estrogen Receptor/ERR (1) Liposome (1) MEK (1) Molecular Glues (1) p38 MAPK (1) PERK (1) Raf (1) Ras (1)
By Research Areas:	Cancer (3)
Oligonucleotides:	Cationic Lipids (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112531B

Poly(2-hydroxyethyl methacrylate) (Mv 300000)	Biochemical Assay Reagents	Others
Poly(2-hydroxyethyl methacrylate) (Mv 300000) is a biocompatible, optically transparent, hydrophilic, and non-degradable polymer with excellent cytocompatibility, eliciting a minimal immunological response from host tissue. Poly(2-hydroxyethyl methacrylate) (Mv 300000) can be used for different biomedical applications, such as bone tissue regeneration, wound dressings and drug delivery .

HY-144014

MVL5	Liposome	Cancer
MVL5 is a non-degradable multivalent cationic lipid. MVL5 is a highly efficient vector for both DNA and siRNA. MVL5 can be used in breast cancer research .

HY-W1048567E

mPEG40000-SCM	Biochemical Assay Reagents	Others
mPEG40000-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .

HY-W1048567A

mPEG2000-SCM	Biochemical Assay Reagents	Others
mPEG2000-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .

HY-W1048567H

mPEG3400-SCM	Biochemical Assay Reagents	Others
mPEG3400-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .

HY-141551B

(R)-GNE-274	Drug Isomer	Others
(R)-GNE-274 is a enantiomer of GNE-274. GNE-274 is a non-degrader that is structurally related to GDC-0927 (estrogen receptor degrader) .

HY-141551

GNE-274	Estrogen Receptor/ERR	Cancer
GNE-274 is a structural analog of the ER degrader GDC-0927 and is a non-degrader. GNE-274 does not induce conversion of ER in breast cancer cell lines and functions as a partial ER agonist (partial ER agonist). GNE-274 increases the chromatin accessibility of ER-DNA binding sites, whereas GDC-0927 does not. GNE-274 is an effective ER ligand binding domain (LBD) inhibitor. GNE-274 can be used in cancer research.

HY-W1048567

mPEG1000-SCM	Biochemical Assay Reagents	Others
mPEG1000-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .

HY-W1048567B

mPEG5000-SCM	Biochemical Assay Reagents	Others
mPEG5000-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .

HY-W1048567D

mPEG20000-SCM	Biochemical Assay Reagents	Others
mPEG20000-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .

HY-W1048567C

mPEG10000-SCM	Biochemical Assay Reagents	Others
mPEG10000-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .

HY-183674

MEK-IN-10	Molecular Glues MEK Raf PERK Ras p38 MAPK Apoptosis	Cancer
MEK-IN-10 is an orally active pan-MEK/RAF non-degrading molecular glue with an IC₅₀ of 782 nM against human MEK1. MEK-IN-10 blocks the phosphorylation of MEK and ERK, induces and stabilizes the MEK1-RAF complex, and disrupts the RAS-MAPK signaling pathway. MEK-IN-10 induces apoptosis in cancer cells and arrests cells at the G0/G1 phase. MEK-IN-10 induces tumor growth inhibition in mouse xenograft models. MEK-IN-10 can be used in the research of RAS-driven cancers, such as colorectal cancer and pancreatic cancer .

Cat. No.	Product Name	Type

HY-144014

MVL5	Biochemical Assay Reagents
MVL5 is a non-degradable multivalent cationic lipid. MVL5 is a highly efficient vector for both DNA and siRNA. MVL5 can be used in breast cancer research .

HY-W1048567E

mPEG40000-SCM	Biochemical Assay Reagents
mPEG40000-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .

HY-W1048567A

mPEG2000-SCM	Biochemical Assay Reagents
mPEG2000-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .

HY-W1048567H

mPEG3400-SCM	Biochemical Assay Reagents
mPEG3400-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .

HY-W1048567

mPEG1000-SCM	Biochemical Assay Reagents
mPEG1000-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .

HY-W1048567B

mPEG5000-SCM	Biochemical Assay Reagents
mPEG5000-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .

HY-W1048567D

mPEG20000-SCM	Biochemical Assay Reagents
mPEG20000-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .

HY-W1048567C

mPEG10000-SCM	Biochemical Assay Reagents
mPEG10000-SCM is a high quality amine-reactive PEG product with a stable non-degradable functional group between the PEG polymer chain and the NHS ester .

Cat. No.	Product Name		Classification

HY-144014

MVL5		Cationic Lipids
MVL5 is a non-degradable multivalent cationic lipid. MVL5 is a highly efficient vector for both DNA and siRNA. MVL5 can be used in breast cancer research .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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