3096958-11-8
Chemical Structure
MEK-IN-10
- CAS No.: 3096958-11-8
- Formula:C22H21ClFN5O5S
- Molecular Weight:521.95
InChIKey: OPPYIRRTQPTSTM-UHFFFAOYSA-N
SMILES: NC(C1=C(NC2=C(C=C(C=C2)C=C)F)N(C(C=C1OC3=C(C(NS(=O)(NC)=O)=CC=C3)Cl)=O)C)=O
Biological Activity: MEK-IN-10 is an orally active pan-MEK/RAF non-degrading molecular glue with an IC50 of 782 nM against human MEK1. MEK-IN-10 blocks the phosphorylation of MEK and ERK, induces and stabilizes the MEK1-RAF complex, and disrupts the RAS-MAPK signaling pathway. MEK-IN-10 induces apoptosis in cancer cells and arrests cells at the G0/G1 phase. MEK-IN-10 induces tumor growth inhibition in mouse xenograft models. MEK-IN-10 can be used in the research of RAS-driven cancers, such as colorectal cancer and pancreatic cancer[1].
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MEK-IN-10 | MEK-IN-10 is an orally active pan-MEK/RAF non-degrading molecular glue with an IC50 of 782 nM against human MEK1. MEK-IN-10 blocks the phosphorylation of MEK and ERK, induces and stabilizes the MEK1-RAF complex, and disrupts the RAS-MAPK signaling pathway. MEK-IN-10 induces apoptosis in cancer cells and arrests cells at the G0/G1 phase. MEK-IN-10 induces tumor growth inhibition in mouse xenograft models. MEK-IN-10 can be used in the research of RAS-driven cancers, such as colorectal cancer and pancreatic cancer. | |||||||||||||||||||||
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Keywords
