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nonhormonal

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By Targets:	3β-HSD (1) Akt (1) Apoptosis (1) CDK (1) DNA/RNA Synthesis (1) Drug Derivative (1) EGFR (1) Epigenetic Reader Domain (5) HSP (1) Isotope-Labeled Compounds (1) Prostaglandin Receptor (1) Reference Standards (1) Ser/Thr Protease (1)
By Research Areas:	Cancer (3) Endocrinology (10)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14281

Trilostane 2 Publications Verification Win 24540	3β-HSD	Endocrinology Cancer
Trilostane (Win 24540) is a competitive and orally active 3-β-hydroxysteroiddehydrogenase (3β-HSD) inhibitor. Trilostane is a synthetic nonhormonal steroid. Trilostane can be used for the research of breast cancer and prostate cancer .

HY-123035

Gamendazole	HSP Akt EGFR	Endocrinology
Gamendazole, an indazole carboxylic acid (ICA), is an orally active, selective HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A) inhibitor. Gamendazole binds to the C-terminal nucleotide binding pocket of HSP90 and cause downregulation of clients AKT1 and ERBB2, but stabilizes the HSP90 heterocomplex. Gamendazole specifically inhibits the actin bundling function of EEF1A1, but does not bind to the nucleotide docking pocket nor inhibits the ribosome charging or protein translation functions of EEF1A1. Gamendazole, an antispermatogenic compound with antifertility effects, has the potential for reversible non-hormonal male contraceptive agent research .

HY-14281R

Trilostane (Standard) Win 24540 (Standard)	Reference Standards Others	Endocrinology Cancer
Trilostane (Standard) is the analytical standard of Trilostane. This product is intended for research and analytical applications. Trilostane (Win 24540) is a competitive and orally active 3-β-hydroxysteroiddehydrogenase (3β-HSD) inhibitor. Trilostane is a synthetic nonhormonal steroid. Trilostane can be used for the research of breast cancer and prostate cancer .

HY-14281S

Trilostane-d3 Win 24540-d₃	Isotope-Labeled Compounds	Others
Trilostane-d₃ is the deuterium-labeled Trilostane (HY-14281). Trilostane-d₃ (Win 24540) is a competitive and orally active 3-β-hydroxysteroiddehydrogenase (3β-HSD) inhibitor. Trilostane-d₃ is a synthetic nonhormonal steroid. Trilostane-d₃ can be used for the research of breast cancer and prostate cancer .

HY-129638

L-10503	Prostaglandin Receptor	Endocrinology
L-10503 is a non-hormonal non-prostaglandin antifertility compound .

HY-122349

Lotrifen L-12717	Drug Derivative	Others
Lotrifen is a non-hormonal compound with abortifacient effects. Lotrifen is most effective when used on the 20th day of pregnancy in beagle and mongrel dogs .

HY-177140

CDD-1147	Epigenetic Reader Domain	Others
CDD-1147 is a BRDT-BD2 inhibitor with an IC₅₀ of 94 nM. CDD-1147 can be used in the research of non-hormonal contraceptives for men .

HY-139741

cyclo(Phe-Ala-Gly-Arg-Arg-Arg-Gly-AEEAc)	DNA/RNA Synthesis	Others
cyclo(Phe-Ala-Gly-Arg-Arg-Arg-Gly-AEEAc) provides an avenue for developing a nonhormonal male contraceptive by blocking of GRTH/DDX25 phosphorylation.

HY-177144

CDD-1128	Epigenetic Reader Domain	Endocrinology
CDD-1128 (Compound 11) is a potent inhibitor of BRDT-BD2. CDD-1128 has an IC₅₀ of 521 nM against BRDT-BD2. CDD-1128 can be studied in research on nonhormonal contraceptive agent .

HY-177143

CDD-1498	Epigenetic Reader Domain	Endocrinology
CDD-1498 (Compound 12) is a potent inhibitor of BRDT-BD2. CDD-1498 has an IC₅₀ of 978 nM against BRDT-BD2. CDD-1498 can be studied in research on nonhormonal contraceptive agent .

HY-177145

CDD-1132	Epigenetic Reader Domain	Endocrinology
CDD-1132 (Compound 8) is a potent inhibitor of BRDT-BD2. CDD-1132 has an IC₅₀ of 13 nM against BRDT-BD2. CDD-1132 can be studied in research on nonhormonal contraceptive agent .

HY-177139

CDD-1349	Epigenetic Reader Domain	Endocrinology
CDD-1349 (Compound 15) is a BRDT-BD2/BRD4-BD2 selective inhibitor. CDD-1349is an analog with sixfold selectivity for BRDT-BD2 versus BRD4-BD2. CDD-1349 has an IC₅₀ of 22 nM against BRDT. CDD-1349 can be studied in research on nonhormonal contraceptive agent .

HY-171129

EP055	Ser/Thr Protease	Endocrinology
EP055 is a non-hormonal male contraceptive. EP055 targets to sperm protein EPPIN and inhibits anti-EPPIN antibodies from binding EPPIN with an IC₅₀ of 1121 μM. EP055 can inhibit sperm motility (IC₅₀ = 199.5 μM) by reducing the internal pH and Ca ²⁺ levels of the sperm, thereby causing the sperm to aggregate. EP055 can be used for development of male contraceptive .

HY-182447

Contragestazol DL111-IT	CDK Apoptosis	Endocrinology Cancer
Contragestazol (DL111-IT) is a non-hormonal antifertility agent. Contragestazol reduces the expression of Cyclin D1 and CDK4, increases the expression of total retinoblastoma protein (pRb), and decreases the level of hyperphosphorylated pRb. Contragestazol induces G₀/G₁ phase cell cycle arrest. Contragestazol inhibits embryonic development by inducing luteal cell apoptosis and reducing intrauterine polyamine levels. Contragestazol exhibits antitumor activity against prostate cancer, S180 tumor and H22 tumor. Contragestazol shows extremely potent activity in terminating early pregnancy in animals .

cyclo(Phe-Ala-Gly-Arg-Arg-Arg-Gly-AEEAc)	DNA/RNA Synthesis	Others
cyclo(Phe-Ala-Gly-Arg-Arg-Arg-Gly-AEEAc) provides an avenue for developing a nonhormonal male contraceptive by blocking of GRTH/DDX25 phosphorylation.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-177139

CDD-1349	other families Phenols Polyphenols Plants Pteris multifida Poir. Source Classification	Epigenetic Reader Domain
CDD-1349 (Compound 15) is a BRDT-BD2/BRD4-BD2 selective inhibitor. CDD-1349is an analog with sixfold selectivity for BRDT-BD2 versus BRD4-BD2. CDD-1349 has an IC₅₀ of 22 nM against BRDT. CDD-1349 can be studied in research on nonhormonal contraceptive agent .

Cat. No.	Product Name	Chemical Structure

HY-14281S

Trilostane-d3
Trilostane-d₃ is the deuterium-labeled Trilostane (HY-14281). Trilostane-d₃ (Win 24540) is a competitive and orally active 3-β-hydroxysteroiddehydrogenase (3β-HSD) inhibitor. Trilostane-d₃ is a synthetic nonhormonal steroid. Trilostane-d₃ can be used for the research of breast cancer and prostate cancer .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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