69095-83-6
Chemical Structure
Contragestazol
Synonym(s): DL111-IT
- CAS No.: 69095-83-6
- Formula:C17H17N3O
- Molecular Weight:279.34
InChIKey: GXCZZAKPGMYPDJ-UHFFFAOYSA-N
SMILES: COC1=CC=CC(C2=NN=C(C3=C(CC)C=CC=C3)N2)=C1
Biological Activity: Contragestazol (DL111-IT) is a non-hormonal antifertility agent. Contragestazol reduces the expression of Cyclin D1 and CDK4, increases the expression of total retinoblastoma protein (pRb), and decreases the level of hyperphosphorylated pRb. Contragestazol induces G0/G1 phase cell cycle arrest. Contragestazol inhibits embryonic development by inducing luteal cell apoptosis and reducing intrauterine polyamine levels. Contragestazol exhibits antitumor activity against prostate cancer, S180 tumor and H22 tumor. Contragestazol shows extremely potent activity in terminating early pregnancy in animals[1][2].
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Contragestazol | Contragestazol (DL111-IT) is a non-hormonal antifertility agent. Contragestazol reduces the expression of Cyclin D1 and CDK4, increases the expression of total retinoblastoma protein (pRb), and decreases the level of hyperphosphorylated pRb. Contragestazol induces G0/G1 phase cell cycle arrest. Contragestazol inhibits embryonic development by inducing luteal cell apoptosis and reducing intrauterine polyamine levels. Contragestazol exhibits antitumor activity against prostate cancer, S180 tumor and H22 tumor. Contragestazol shows extremely potent activity in terminating early pregnancy in animals. | |||||||||||||||||||||
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- [1]. Yang B, et al. Antiproliferative activity of contragestazol (DL111-IT) in murine and human tumor models in vitro and in vivo. Cancer Chemother Pharmacol. 2006;57(2):268-273. [Content Brief]
- [2]. He QJ, et al. Contragestazol (DL111-IT) inhibits proliferation of human androgen-independent prostate cancer cell line PC3 in vitro and in vivo. Asian J Androl. 2005 Dec;7(4):389-93. [Content Brief]
Keywords
