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polyubiquitin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Deubiquitinase (1) E1/E2/E3 Enzyme (2) IFNAR (1) NF-κB (1) PROTAC Linkers (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (1)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-176426

Subquinocin	Deubiquitinase NF-κB IFNAR	Cancer
Subquinocin is a tumor suppressor CYLD inhibitor that inhibits USP family deubiquitinases (DUBs) activity of CYLD with an IC₅₀ of 30 μM. Subquinocin enhances the activation of NF-κB and IFN pathways by inhibiting CYLD. Subquinocin promotes RIG-I-mediated activation of IRF3/IRF7 in the interferon pathway. Subquinocin can be used for the research of cancer and neurodegenerative diseases .

HY-153775

UC-764864	E1/E2/E3 Enzyme Apoptosis	Cancer
UC-764864 is a selective UBE2N inhibitor. UC-764864 covalently binds UBE2N catalytic Cys87, blocks ubiquitin-UBE2N thioester formation and polyubiquitin chain synthesis. UC-764864 blocks ubiquitination of innate immune- and inflammatory-related substrates, and induces cell apoptosis. UC-764864 can be used for the research of acute myeloid leukemia .

HY-138165

Ac-Phe-NH2	E1/E2/E3 Enzyme	Others
Ac-Phe-NH2 is a non-competitive inhibitor of polyubiquitin chain elongation at K_i value of 8 mM by destabilizing the active trimer .

HY-164951

C1-BCEA-Acm	PROTAC Linkers	Others
C1-BCEA-Acm is a linker, that can be used for synthesis of polyubiquitin chains and ubiquitin-modified substrates .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990493

*Anti-Polyubiquitin* Antibody**	Inhibitory Antibodies	Inflammation/Immunology
The Anti-Polyubiquitin Antibody is a human-derived antibody expressed in CHO, targeting *Polyubiquitin. The Anti-Polyubiquitin* Antibody carries huIgG1 type heavy chains and huκ type light chains, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-Polyubiquitin Antibody can be referenced with Human IgG1 kappa, Isotype Control (HY-P99001).

Species:	Human (3)
Tag:	His (1) Tag Free (2)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71101

	UBB Protein, Human polyubiquitin-B; UBB	Human	E. coli
	UBB proteins are central regulators of the formation of covalently linked isopeptide bonds in different states: monoubiquitin, polyubiquitin chains, or linear polyubiquitin. UBB Protein, Human is the recombinant human-derived UBB protein, expressed by E. coli , with tag free.

HY-P701839

	ubiquitin Protein, Human (His) UBC; polyubiquitin-C	Human	E. coli
	Ubiquitin is a multifunctional protein that can form covalently linked isopeptide bonds in various states, including mono- and polyubiquitin chains. ubiquitin Protein, Human (His) is the recombinant human-derived ubiquitin protein, expressed by E. coli , with N-His labeled tag.

HY-P704952

	UBB Protein, Human (75a.a, His) polyubiquitin-B; UBB	Human	E. coli

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Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (2) IP (1) DotBlot (1) WB (2) FC (1) ELISA (1)
Isotype:	IgG (1) IgG/Kappa (1)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

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HY-P86479

	Ubiquitin K48 Antibody (YA6171) UBB; polyubiquitin-B; UBC; polyubiquitin-C; RPS27A; UBA80; UBCEP1; Ubiquitin-40S ribosomal protein S27a; Ubiquitin carboxyl extension protein 80; UBA52; UBCEP2; Ubiquitin-60S ribosomal protein L40; CEP52; Ubiquitin A-52 residue ribosomal pr; Ubiquitin K48;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Ubiquitin K48 Antibody (YA6171) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ubiquitin K48.

HY-P87377

	*K27-linkage Specific Ubiquitin* Antibody (YA7060)** Epididymis secretory protein Li 50 antibody; FLJ25987 antibody; HEL S 50 antibody; MGC8385 antibody; polyubiquitin B antibody; RPS 27A antibody; RPS27A antibody; UBA 52 antibody; UBA 80 antibody; UBA52 antibody	WB, IHC-P, ICC/IF, FC, DotBlot	Human, Mouse, Rat
	K27-linkage Specific Ubiquitin Antibody (YA7060) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to K27-linkage Specific Ubiquitin.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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