6 Results for "

single chain variable fragment

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "single chain variable fragment" in MCE Product Catalog:

Referencia número: HY-P990688
No. CAS: 2559056-68-5
Synonyms: AMG-509

Target:  

CD3

Áreas de investigación:  

Cancer

Xaluritamig (AMG-509) is a bispecific T cell engager and cytolytic agent with a Kd of 27.6 nM for human CD3ε. Xaluritamig binds to CD3ε via an anti-CD3 single-chain variable fragment (scFv) domain, and to STEAP1 via a bispecific anti-STEAP1 antigen-binding fragment (Fab) domain, thereby recruiting and activating T cells and forming a bridge between T cells and STEAP1-expressing cancer cells. Xaluritamig induces T cell-mediated redirected cytotoxicity, tumor cell lysis, cytokine release, CD8 + T cell activation and expansion, as well as tumor stasis or regression. Xaluritamig contains an Fc domain with no effector function, which prolongs serum half-life, exhibits only minimal activity against cells with low STEAP1 expression and normal cells, and shows extremely low target-related off-tumor toxicity in cynomolgus monkeys. Xaluritamig is used in STEAP1×CD3 XmAb 2+1 immunotherapy and in research on metastatic castration-resistant prostate cancer and Ewing sarcoma .
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Referencia número: HY-P990534
Synonyms: K1-70

Target:  

TSH Receptor

Áreas de investigación:  

Endocrinology Cancer

Anti-TSHR Antibody (K1-70) is an anti-TSHR monoclonal antibody. Anti-TSHR Antibody (K1-70) incorporates a single-chain variable fragment into a chimeric antigen receptor to redirect T cells to TSHR-expressing cells. Anti-TSHR Antibody (K1-70) shows antitumor activity with no apparent toxicity. Anti-TSHR Antibody (K1-70) can be used for the research of differentiated thyroid cancer (DTC) .
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Referencia número: HY-P990714
No. CAS: 2750126-32-8

Target:  

CD3

Áreas de investigación:  

Inflammation/Immunology

Obertamig is an engineered, humanized, anti-CD3E/HLA-G monoclonal antibody with humanized CH2-CH3 modifications and consists of half immunoglobulin IgG1 λ2 and a single-chain variable fragment (scFv) .
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Referencia número: HY-P99825
No. CAS: 2171034-70-9

Target:  

Inhibitory Antibodies

Áreas de investigación:  

Inflammation/Immunology Cancer

Relfovetmab is a monoclonal antibody and also serves as a single-chain variable fragment component for engineering chimeric antigen receptors (CAR) in modified CAR-T cells. Relfovetmab can be used in studies of cancer and immune disorders .
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Referencia número: HY-P990695
No. CAS: 2642197-17-7

Target:  

EGFR

Áreas de investigación:  

Inflammation/Immunology

Lunaxafusp is an anti-ERBB2 scFv-heavy-κ monoclonal antibody composed of a single chain variable fragment, an antibody heavy chain, and a kappa antibody light chain .
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Referencia número: HY-P992232

Target:  

RET

Áreas de investigación:  

Inflammation/Immunology

Anti-GFRA4 Antibody (scFv) is a recombinant single-chain antibody fragment targeting GFRA4. Anti-GFRA4 Antibody (scFv) is formed by connecting the variable region of the heavy chain (VH) and the variable region of the light chain (VL) through a flexible short peptide (Linker), without the Fc segment, while maintaining the antigen-binding specificity.
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