2. GPCR/G Protein
  3. TSH Receptor
  4. Anti-TSHR Antibody (K1-70)

Anti-TSHR Antibody (K1-70)  (Synonyms: K1-70)

Cat. No.: HY-P990534 Purity: 98.57%
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Anti-TSHR Antibody (K1-70) is an anti-TSHR monoclonal antibody. Anti-TSHR Antibody (K1-70) incorporates a single-chain variable fragment into a chimeric antigen receptor to redirect T cells to TSHR-expressing cells. Anti-TSHR Antibody (K1-70) shows antitumor activity with no apparent toxicity. Anti-TSHR Antibody (K1-70) can be used for the research of differentiated thyroid cancer (DTC).

For research use only. We do not sell to patients.

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Description

Anti-TSHR Antibody (K1-70) is an anti-TSHR monoclonal antibody. Anti-TSHR Antibody (K1-70) incorporates a single-chain variable fragment into a chimeric antigen receptor to redirect T cells to TSHR-expressing cells. Anti-TSHR Antibody (K1-70) shows antitumor activity with no apparent toxicity. Anti-TSHR Antibody (K1-70) can be used for the research of differentiated thyroid cancer (DTC)[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

TSHR
In Vitro

Anti-TSHR Antibody (K1-70) can be used to generate anti-TSHR CAR-T cells, which exhibit robust proliferative capacity, lower apoptosis levels, and can maintain a memory-like CD8+ T cell subset with a less differentiated state[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-TSHR Antibody (K1-70) Related Antibodies
In Vivo

Anti-TSHR Antibody (K1-70) (5×106 70-CAR T cells; i.v.; single dose) induces significant DTC tumor regression, prolongs mouse survival, and exhibits a favorable safety profile in the NSG mouse xenograft model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD-SCID IL2rgnull (NSG) (8-week-old)[1]
Dosage: 5×106 70-CAR T cells (derived from Anti-TSHR Antibody (K1-70))
Administration: I.v.; single dose
Result: Induced tumor growth arrest at day 16, with tumor volume shrinking until day 40, and significantly reduced tumor burden compared to control groups.
Increased abundance of tumor-infiltrating CD3+ T cells compared to control groups, with infiltration increasing over time.
Significantly postponed metastatic focus formation in the lungs.
Caused no significant changes in mouse body weight, diet, water consumption, or physiological behavior, and no histological damage or T lymphocyte infiltration in major visceral organs.
Gene ID

7253  [NCBI]

Accession

P16473-1 / NP_000360.2
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

143.54 kDa

Appearance

Liquid

Color

Colorless to light yellow

Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized TSHR Protein, Human can bind Anti-TSHR Antibody (K1-70). The EC50 for this effect is 851.2 ng/mL.
Purity & Documentation

Purity: 98.57%

SDS (251 KB)

COA (232 KB) SDS-PAGE (89 KB) SEC-HPLC (119 KB)

Inhibitory Antibodies User Guide (603 KB)
References
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Anti-TSHR Antibody (K1-70) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-TSHR Antibody (K1-70)K1-70TSH ReceptorThyrotropin receptorThyroid-stimulating hormone Receptorthyroid cancerK1-TSHRTSH receptorTSHR-expressing cellsIL-2CD8+ T cell subsetsBCPAP-TSHRT cellsxenograft mouse modelsinterferon-γInhibitorinhibitorinhibit

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