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101 Results for "
sn-2 position
" in MedChemExpress (MCE) Product Catalog:
Products (101)
101 Results for "sn-2 position" in MCE Product Catalog:
3
3 Cited Publications
Synonyms: Dioleoylphosphatidylglycerol sodium
1
Target:
Áreas de investigación:
Phospholipase A2 (PLA2) is a calcium-dependent, heat-stable enzyme that catalyzes the hydrolysis of glycerophospholipids at the sn-2 position of cellular membranes, thereby releasing Arachidonic Acid (AA) (HY-109590). Phospholipase A2 is a key mediator in the biosynthesis of pro-inflammatory lipid mediators, critically involved in inflammatory processes. Phospholipase A2 can be used for cardiovascular and inflammatory diseases research .
1
1 Cited Publications
Referencia número: HY-175067
Synonyms: DHPI-4,5-P2 sodium salt; PI(4,5)P2 (6:0/6:0) sodium salt; PIP2[4',5'](6:0/6:0) sodium salt
Target:
Áreas de investigación:
PtdIns-(4,5)-P2 (1,2-dihexanoyl) (sodium salt) is a synthetic analog of natural Ptdlns with C6:0 fatty acids at the sn-1 and sn-2 positions.
Referencia número: HY-112747
No. CAS: 97281-51-1
Synonyms: LPI; PE (soy)
Target:
Áreas de investigación:
Soy PE (LPI) is the most abundant phospholipid in prokaryotes and the second most abundant found in the membrane of mammalian, plant, and yeast cells, comprising approximately 25% of total mammalian phospholipids. In the brain, phosphatidylethanolamine comprises almost half of the total phospholipids. It is synthesized mainly through the cytidine diphosphate-ethanolamine and phosphatidylserine decarboxylation pathways, which occur in the endoplasmic reticulum (ER) and mitochondrial membranes, respectively. It is a precursor in the synthesis of phosphatidylcholine and arachidonoyl ethanolamide and is a source of ethanolamine used in various cellular functions. In E.coli, phosphatidylethanolamine deficiency prevents proper assembly of lactose permease, suggesting a role as a lipid chaperone. It is a cofactor in the propagation of prions in vitro and can convert recombinant mammalian proteins into infectious molecules even in the absence of RNA. This product contains phosphatidylethanolamine molecular species with variable fatty acyl chain lengths at the sn-1 and sn-2 positions .
Referencia número: HY-W019833
No. CAS: 76343-22-1
Synonyms: PC(14:0/18:0); 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphocholine
Target:
Referencia número: HY-115701
No. CAS: 154436-49-4
Synonyms: 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-phosphoethanolamine; 15(S)-HpETE-SAPE; 15(S)-hydroperoxyeicostetraenoic acid-SAPE
Target:
Áreas de investigación:
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-Pe (SAPE) by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3.
Referencia número: HY-W674124
No. CAS: 7370-46-9
Synonyms: TG(15:0/15:0/15:0); 1,2,3-Tripentadecanoyl glycerol
Target:
Áreas de investigación:
Tripentadecanoin (TG(15:0/15:0/15:0)) is a triacylglycerol that contains pentadecanoic acid (HY-W004283) at the sn-1, sn-2, and sn-3 positions.
Referencia número: HY-W040185
No. CAS: 80724-31-8
Synonyms: 1,2-DPPA sodium; PA(14:0/14:0) sodium; 1,2-Dimyristoyl-sn-glycero-3-phosphate sodium
Target:
Áreas de investigación:
1,2-Dimyristoyl-sn-glycero-3-phosphate monosodium is a phospholipid containing the long-chain (14:0) myristic acid inserted at the sn-1 and sn-2 positions. It can be used in the generation of micelles, liposomes, and other types of artificial membranes.
Synonyms: 18:0p/20:4-PE; C18(Plasm)-20:4-PE; PE(P-18:0/20:4)
Target:
Áreas de investigación:
1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PE (18:0p/20:4-PE; C18(Plasm)-20:4-PE) is a plasmalogen that contains 1(Z)-octadecenoic acid and arachidonic acid (HY-109590) at the sn-1 and sn-2 positions, respectively.
Synonyms: 1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine; PAPC; PC(16:0/20:4)
Áreas de investigación:
1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PC (PAPC) is a phospholipid containing palmitic acid (16:0) and arachidonic acid (20:4) at the sn-1 and sn-2 positions, respectively, that is found in biological membranes. PAPC is oxidized in vivo, and its oxidation products are involved in chronic inflammation and vascular disease. PAPC has been used to study signaling of oxidized phospholipids. Levels of PAPC are decreased in isolated human multiple myeloma cells.
Referencia número: HY-W440981
No. CAS: 59403-53-1
Synonyms: 1-Stearoyl-2-palmitoyl-sn-glycero-3-phosphocholine
SPPC is a phospholipid with different length of fatty acid. The sn-1 position contains a stearic acid (18:0) while the sn-2 position is occupied by a palmitic acid (16:0).
Referencia número: HY-W704966
No. CAS: 4421-58-3
Target:
Áreas de investigación:
2-Stearoyl-sn-glycero-3-PC is a lysophospholipid that contains stearic acid (HY-B2219) at the sn-2 position. It has been found in rabbit myocardium.
Synonyms: 16:0 Diether PC
Target:
Áreas de investigación:
1,2-Di-O-hexadecyl-sn-glycero-3-phosphocholine (16:0 Diether PC) is a synthetic ether-linked phospholipid containing hexadecyl groups at the sn-1 and sn-2 positions. It is commonly used in the generation of liposomes and artificial membranes to study membrane dynamics.
Synonyms: C18(plasm)-20:4-PC; 18:0p/20:4-PC; PC(P-18:0/20:4)
Target:
Áreas de investigación:
1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PC is a plasmalogen that contains 1(Z)-octadecenoic acid and arachidonic acid (HY-109590) at the sn-1 and sn-2 positions, respectively. It scavenges singlet oxygen in a cell-free assay.
Referencia número: HY-W583869
No. CAS: 6418-95-7
Synonyms: 1-Stearoyl-2-Oleoyl-sn-glycero-3-PE; 18:0-18:1 PE; PE(18:0/18:1)
Target:
Áreas de investigación:
1-Stearoyl-2-oleoyl-sn-glycerol-3-phosphoethanolamine is a phospholipids that contains stearic acid and oleic acid at the sn-1 and sn-2 positions, respectively. It has been used in the generation of lipid nanoparticles (LNPs) for in vitro delivery of mRNA or nuclear-targeted plasmid DNA.
Referencia número: HY-W440983
No. CAS: 59403-52-0
Synonyms: PC(18:0/22:6); DHA-PC; 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine
Target:
Áreas de investigación:
SDPC (DHA-PC) is a new generation of omega-3 lipids, which contains an ester bond linking DHA at the sn-2 position of phospholipid. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine exerts anti-angiogenesis effect through activating PPARγ. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine significantly declines the proliferation, migration, tube formation of human umbilical vein endothelial cells. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine has the potential for anti-tumor angiogenesis research .
Target:
Áreas de investigación:
ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A2 (sPLA2s) with an IC50 of 80 nM, specially targeting hGX. ROC-0929 inhibits the phosphorylation of ERK1/2 and p-38. Secreted phospholipases A2 (sPLA2s) are a family of disulfide-rich, Ca 2+-dependent enzymes that hydrolyze the sn-2 position of glycero-phospholipids to release a fatty acid and a lysophospholipid. ROC-0929 has the potential for researching inflammation related diseases .
Referencia número: HY-W440958
No. CAS: 59403-51-9
Synonyms: PSPC; PC(16:0-18:0)
1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphocholine is an assymetrical phospholipid containing saturated palmitic and stearic acid at the sn-1 and sn-2 position respectively. The phosphate group is attached to choline.
Synonyms: PAzePC; Azelaoyl PC; 1-Palmitoyl-2-Azelaoyl PC
Target:
Áreas de investigación:
Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were isolated and purified from oxLDL and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. PAz-PC (Azelaoyl PC) is one of the predominant oxLDL species and may be one of the important structural determinants of oxLDL.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
