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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
thiazole derivative
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "thiazole derivative" in MCE Product Catalog:
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Tropinone is an organic synthesis intermediate and a skeleton for constructing derivatives containing thiazole rings and other structures. Tropinone derivatives have anticancer activities such as inducing tumor cell apoptosis and inhibiting tyrosinase activity, and can be used in research such as anticancer drug development and tyrosinase inhibitor design .
Cat. No.: HY-115406A
CAS No.: 2321332-57-2
CPTH6 hydrobromide is a thiazole derivative which activates apoptotic program and increases autophagic features in human acute myeloid leukemia cell lines. CPTH6 can be used for cancer research .
Cat. No.: HY-153847
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RNA Aptamer Mango Ⅱ (sodium) has an exceptionally high affinity to TO1-biotin (a thiazole orange derivative fluorophore), and can be used to visualize RNA expression or localization in live cells. Compared to the original Mango I aptamer, RNA Aptamer Mango Ⅱ (sodium) has markedly improved fluorescent properties, binding affinities, and salt dependencies.
Cat. No.: HY-59343
CAS No.: 61296-22-8
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2-Amino-5-bromothiazole hydrobromide is an aminothiazole and brominated thiazole derivative. 2-Amino-5-bromothiazole hydrobromide induces base-pair substitutions in bacterial test organisms. 2-Amino-5-bromothiazole hydrobromide exhibits mutagenic activity in Klebsiella pneumoniae and Salmonella typhimurium. 2-Amino-5-bromothiazole hydrobromide acts as a Hg 2+-binding moiety in rhodamine-based fluorescent chemical sensors .
Cat. No.: HY-W010594
CAS No.: 1003-04-9
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5'-GGCACGUACGAAGGGACGGUGCGGAGAGGAGAGUACGUGC-3', sodium salt
Cat. No.: HY-153846
Cat. No.: HY-178994
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DENV-IN-14 (Compound 3c) is a thiazole hydrazone derivative with anti-dengue virus (DENV) activity with an EC50 of 0.01 μM and the selectivity index (SI) of 200. DENV-IN-14 exhibits rapid plasma clearance and its metabolic stability is limited. DENV-IN-14 can be used for research on dengue fever .
Cat. No.: HY-175024
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MC12 is a thiazole-based derivative and a SARS-CoV-2 main protease inhibitor (IC50: 77.7 nM). MC12 exhibits inhibitory effects on both SARS-CoV and SARS-CoV-2 main proteases, with low cytotoxicity and good stability. MC12 can be used in the research of anti-COVID-19 drugs .
Cat. No.: HY-114813
CAS No.: 1497249-95-2
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KHG26693 is a thiazole derivative with anti-inflammatory and antioxidant properties. KHG26693 normalizes disturbed glucose metabolism by enhancing glucose utilization and decreasing liver glucose production via insulin release. KHG26693 is promising for research of diabetes .
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5'-GGCACGUAC-CGA-GG-GAGU-GG- UGA -GG-AUGA- -GG-CGA-----GUACGUGC-3', sodium salt
Cat. No.: HY-153848
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5'-GGCACGUACGAAGGAAGGAUUGGUAUGUGGUAUAUUCGUACGUGCC-3', sodium salt
Cat. No.: HY-153849
Cat. No.: HY-146123
CAS No.: 2691937-03-6
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ATX inhibitor 20 (compound 24) is a potent ATX (autotaxin) inhibitor, with an IC50 of 2.3 nM .
Cat. No.: HY-W010594R
CAS No.: 1003-04-9
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Cat. No.: HY-121856
CAS No.: 36740-73-5
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Flumizole, a derivative of substituted 5,6-diaryl-2,3-dihydroimidazo[2,1-b]thiazoles, was synthesized and evaluated for its immunoregulatory and anti-inflammatory properties in animal models such as rat adjuvant-induced arthritis and mouse oxazolone-induced contact sensitivity assays. This compound class combines structural elements from flumizole and levamisole, aiming to enhance therapeutic efficacy. Symmetrically substituted 5,6-diaryl compounds with specific alkyl heteroatom or halogen substitutions showed optimal potency in the arthritis model. However, variations in activity were less consistent in the contact sensitivity assay. Flumizole and related compounds demonstrate potential as dual-action agents, targeting inflammation and immune modulation, offering promise for therapeutic development in immune-related disorders .
Cat. No.: HY-106793
CAS No.: 105523-37-3
Synonyms: HBW-538
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Tiprotimod (HBW-538) is a synthetic thiazole derivative. Tiprotimod is a potent immunopotentiator for humoral and cell-mediated immune response in animal models .
Cat. No.: HY-169117
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α-Glucosidase-IN-74 (Compound 7d), an isatin-thiazole derivative, is a α-glucosidase inhibitor. α-Glucosidase-IN-74 exhibits antidiabetic activity by decreasing glycaemia and triglyceride levels in Streptozotocin (HY-13753)-induced diabetic animals .
Cat. No.: HY-118972
CAS No.: 1250849-11-6
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TPI-1917-49 is an agent that can cross the blood-brain barrier and reduce amyloid β (Aβ). TPI-1917-49 reduces the production of Aβ peptide segments by promoting the non-amyloidogenic pathway of amyloid precursor protein (APP) (increasing the generation of sAPPα mediated by α-secretase). TPI-1917-49 reduces amyloid plaques in mouse models. TPI-1917-49 can be used in Alzheimer's disease research .
Cat. No.: HY-165564
CAS No.: 113759-19-6
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SM-8849 is a thiazole derivative with anti-arthritis activity. SM-8849 specifically targets and inactivates T cells involved in delayed-type hypersensitivity (DTH) reactions, thereby inhibiting the core immunopathological process of arthritis, but has little effect on the humoral immune process such as antibody production. In a mouse arthritis model induced by Type II Collagen (HY-NP003), SM-8849 significantly alleviated clinical symptoms, reduced bone destruction and joint damage. SM-8849 can be used for the study of autoimmune diseases such as rheumatoid arthritis .
Cat. No.: HY-181493
Research Areas:
VEGFR-2-IN-81 is a thiazole-based isoquinolin-1(2H)-one derivative and an VEGFR-2 inhibitor with IC50 of 1.94 μM. VEGFR-2-IN-81 exhibits significant selective cytotoxicity against colorectal cancer cells (IC50 = 7.75 μM). VEGFR-2-IN-81 exerts anti-colorectal cancer effects by inducing apoptosis, elevating intracellular ROS levels and reducing mitochondrial transmembrane potential. VEGFR-2-IN-81 can be used for the research of colorectal cancer, lung cancer, breast cancer, liver cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
