SM-8849
SM-8849 is a thiazole derivative with anti-arthritis activity. SM-8849 specifically targets and inactivates T cells involved in delayed-type hypersensitivity (DTH) reactions, thereby inhibiting the core immunopathological process of arthritis, but has little effect on the humoral immune process such as antibody production. In a mouse arthritis model induced by Type II Collagen (HY-NP003), SM-8849 significantly alleviated clinical symptoms, reduced bone destruction and joint damage. SM-8849 can be used for the study of autoimmune diseases such as rheumatoid arthritis.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 113759-19-6
- 화학식: C18H17FN2S
- 분자량:312.40
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
Chemical Information
-
CAS No. 113759-19-6
-
분자량 312.40
-
화학식 C18H17FN2S
-
SMILES
FC1=C(C2=CC=CC=C2)C=CC(C(C)C3=CSC(NC)=N3)=C1
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Nagai H, et al. The effect of SM-8849 on experimental arthritis in mice. Pharmacology. 1996 Jun;52(6):377-86. [Content Brief]
[2]. Nishikaku F, Koga Y. Suppression of murine collagen-induced arthritis by treatment with a novel thiazole derivative, SM-8849. Immunopharmacology. 1993 Jan-Feb;25(1):65-74. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SM-8849 Related Classifications
HY-165564 Related Classifications
Powered by Bioz