2 Results for "

withanolide derivative

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "withanolide derivative" in MCE Product Catalog:

Withanoside V
Withanoside V
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Cat. No.: HY-N8671
CAS No.: 256520-90-8
Category:  

Withania somnifera Plants Solanaceae Steroids

Target:  

Amyloid-β Apoptosis Reactive Oxygen Species (ROS) SARS-CoV

Withanoside V is a blood-brain barrier-permeable withanolide derivative . Withanoside V binds strongly to Sudlow I (domain IIA) of human serum albumin (HSA) to form a stable complex and alter the secondary structure of albumin, thereby increasing helix content and reducing β-sheet and random coil. Withanoside V binds to Aβ (1-42) to block the interaction between monomers and subsequent aggregation. Withanoside V inhibits the viability of neuroblastoma cells, reduces the number of apoptotic cells induced by Aβ (1-42), and decreases ROS production. Withanoside V inhibits SARS-CoV-2 Mpro. Withanoside V can be used for research on Alzheimer's disease and coronavirus disease 2019 .
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Withanoside IV
Withanoside IV
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Cat. No.: HY-N8693
CAS No.: 362472-81-9
Category:  

Withania somnifera Plants Solanaceae Steroids

Target:  

COX Amyloid-β Sirtuin Reactive Oxygen Species (ROS) Apoptosis SARS-CoV

Withanoside IV is an orally active, blood-brain barrier-permeable withanolide derivative. Withanoside IV specifically binds to the Sudlow I site of HSA, induces secondary structural changes in HSA, and forms stable HSA complexes. Withanoside IV inhibits the enzymatic activity of COX-2. Withanoside IV induces axonal regeneration, peripheral nervous system myelination and increased axonal density in spinal cord tissue, reduces reactive gliosis-related changes, and improves hindlimb motor function. Withanoside IV binds to amyloid-β 1-42 to inhibit its aggregation, induces neurite outgrowth and synapse reconstruction, repairs damaged axons and dendrites, enhances mitochondrial biogenesis, exerts neuroprotective effects via the BDNF and SIRT1 signaling pathways, reduces ROS production and neuronal apoptosis, and ameliorates memory deficits. Withanoside IV inhibits the activity of the SARS-CoV-2 main protease. Withanoside IV can be used in research related to spinal cord injury, Alzheimer's disease, and coronavirus disease 2019 (COVID-19) .
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