EIF1AX - eukaryotic translation initiation factor 1A X-linked Gene

Also Known as EIF1A; EIF4C; eIF-1A; eIF-4C; EIF1AP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1964

About EIF1AX

Cytogenetic location: Xp22.12 Genomic coordinates (GRCh38): X:20,124,525-20,141,838 (from NCBI)

This gene has 2 transcripts (splice variants), 254 orthologues, 1 paralogue and is associated with 69 phenotypes. Ubiquitous expression in thyroid (RPKM 20.5), endometrium (RPKM 20.0) and 25 other tissues.

Summary

This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008]

EIF1AX Products (1)

mRNA	Protein	Name
NM_001412.4	NP_001403.1	eukaryotic translation initiation factor 1A, X-chromosomal

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21139563	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ribosome assembly	IDA IDA: Inferred from direct assay	35732735	GOA
involved in translational initiation	IDA IDA: Inferred from direct assay	9732867	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of eukaryotic 43S preinitiation complex	IDA IDA: Inferred from direct assay	9732867	GOA
part of eukaryotic 48S preinitiation complex	IDA IDA: Inferred from direct assay	9732867	GOA
part of multi-eIF complex	IDA IDA: Inferred from direct assay	9732867	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF1AX Protein Structure

eIF-1a

0
100
144 a.a.

Protein Preferred Names	Protein Names
eukaryotic translation initiation factor 1A, X-chromosomal	Putative eukaryotic translation initiation factor 1A

EIF1AX Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EIF1AX	P47813	EIF3C	Homo sapiens	Q99613	Pull Down	23623729
Intra	EIF1AX	P47813	EIF3A	Homo sapiens	Q14152	Pull Down	23623729
Intra	EIF1AX	P47813	IPO13	Homo sapiens	O94829	X-Ray Diffraction	23435562
Intra	EIF1AX	P47813	IPO13	Homo sapiens	O94829	GMS	23435562
Intra	EIF1AX	P47813	IPO13	Homo sapiens	O94829	TSA	23435562

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EIF1AX Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70355	EIF1AX Protein, Human (His)	P47813 (M1-I144)	≥ 95%, as determined by reducing SDS-PAGE.

EIF1AX Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80649	eIF1A Antibody (YA466)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P80649A	eIF1A Antibody (YA466)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Differentiated Thyroid Carcinoma	Papillary Or Follicular Thyroid Carcinoma Well-Differentiated Thyroid Carcinoma Differentiated Thyroid Gland Carcinoma
Choroid Cancer	Choroid Neoplasm Choroidal Tumor Malignant Tumor Of Choroid Malignant Tumor Of The Choroid Neoplasm Of Choroid Choroid Neoplasms Primary Malignant Neoplasm Of Choroid
Posterior Uveal Melanoma	Medium/Large Size Posterior Uveal Melanoma Small Size Posterior Uveal Melanoma Ciliary Body And Choroid Melanoma, Medium/Large Size Ciliary Body And Choroid Melanoma, Small Size
Malignant Choroid Melanoma	Malignant Melanoma Of Choroid Melanoma Of The Choroid
Plasma Cell Neoplasm	Plasma Cell Dyscrasia Paraproteinemias Plasma Cell Tumour Plasmacytic Tumor Multiple Myeloma Plasmacytoma Plasma Cell Tumours Plasma Cells Dyscrasia
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Epithelioid Cell Melanoma	Epithelioid Melanoma
Malignant Conjunctival Melanoma	Conjunctival Melanoma Malignant Melanoma Of Conjunctiva Conjunctival Malignant Melanoma
Meningeal Melanoma	Melanoma Of The Leptomeninges Leptomeningeal Melanoma
Malignant Leptomeningeal Tumor	Malignant Leptomeningeal Tumour Malignant Tumor Of Leptomeninges Malignant Tumour Of Leptomeninges Malignant Leptomeningeal Neoplasm
Thyroid Gland Cancer	Thyroid Gland Carcinoma Malignant Neoplasm Of Thyroid Gland Malignant Tumour Of Thyroid Gland Thyroid Neoplasm Thyroid Neoplasms Neoplasm Of Thyroid Gland Thyroid Gland Neoplasm Head And Neck Cancer, Thyroid Neoplasm Of The Thyroid Gland Cancer Of The Thyroid Primary Malignant Neoplasm Of Thyroglossal Duct Malignant Neoplasm Of Thyroglossal Duct Primary Malignant Neoplasm Of Thyroid Gland Thyroglossal Duct Cancer Toxic Goitre Malignant Tumour Cancerous Goitre
Conjunctival Cancer	Malignant Neoplasm Of Conjunctiva Conjunctival Neoplasms Conjunctival Tumor Malignant Conjunctival Tumor Malignant Tumor Of Conjunctiva Neoplasm Of Conjunctiva Conjunctiva Cancer Primary Malignant Neoplasm Of Conjunctiva
Ovarian Endometrioid Adenofibroma
Meningeal Melanocytoma	Leptomeningeal Melanocytoma Melanocytoma Of Meninges
Central Nervous System Melanocytic Neoplasm	Primary Melanocytic Lesion Of Meninges Central Nervous System Primary Melanocytic Lesion Melanocytic Tumor Of The Cns Primary Melanocytic Lesions Of The Cns
Meningeal Melanomatosis	Leptomeningeal Melanomatosis
Uveal Disease	Uveal Diseases
Ocular Melanoma	Intraocular Melanoma Uveal Melanoma Eye Melanoma Melanoma Of Eye Melanoma Of The Uvea Malignant Melanoma Of Eye
Diffuse Meningeal Melanocytosis	Diffuse Melanocytosis Diffuse Melanosis
Thyroid Gland Follicular Carcinoma	Follicular Thyroid Carcinoma Follicular Adenocarcinoma Follicular Adenocarcinoma, Well Differentiated Follicular Carcinoma Thyroid Adenocarcinoma Adenocarcinoma, Follicular
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Thyroid Gland Anaplastic Carcinoma	Anaplastic Thyroid Carcinoma Anaplastic Thyroid Cancer Thyroid Cancer, Anaplastic Thyroid Carcinoma, Anaplastic Thyroid Carcinoma Anaplastic
Multinodular Goiter
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 Melanoma, Malignant CMM1 Melanoma, Cutaneous Malignant Cmm Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04238	EIF1AX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20152	Eif1ax Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26656	Eif1ax Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	EIF1AX	VGNC	VGNC:54830
Rattus norvegicus	EIF1AX	RGD	RGD:1560198
Bos taurus	EIF1AX	VGNC	VGNC:56706
Mus musculus	EIF1AX	MGD	MGI:1913485
Others	EIF1AX	NCBI