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ODF1 - outer dense fiber of sperm tails 1 Gene

Also Known as ODF; RT7; ODF2; ODFP; SODF; CT133; ODF27; ODFPG; HSPB10; ODFPGA; ODFPGB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4956

About ODF1

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:102,551,589-102,561,018 (from NCBI)

This gene has 2 transcripts (splice variants) and 107 orthologues. Restricted expression toward testis (RPKM 125.7).

Summary

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein. [provided by RefSeq, Jul 2008]

ODF1 Products (1)

mRNA	Protein	Name
NM_024410.4	NP_077721.2	outer dense fiber protein 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21597245	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ODF1 Protein Structure

HSP20

0
100
200
250 a.a.

Protein Preferred Names	Protein Names
outer dense fiber protein 1	cancer/testis antigen 133

ODF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ODF1	Q14990	KRTAP12-2	Homo sapiens	P59991	Y2H Prey Pooling	25416956
Intra	ODF1	Q14990	LCE1C	Homo sapiens	Q5T751	Y2H Prey Pooling	32296183
Intra	ODF1	Q14990	LCE1C	Homo sapiens	Q5T751	Y2H Array	32296183
Intra	ODF1	Q14990	LCE1C	Homo sapiens	Q5T751	Validated Y2H	32296183
Intra	ODF1	Q14990	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	ODF1	Q14990	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	ODF1	Q14990	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	ODF1	Q14990	P4HB	Homo sapiens	P07237	Y2H Array	32296183
Intra	ODF1	Q14990	P4HB	Homo sapiens	P07237	Y2H Prey Pooling	32296183
Intra	ODF1	Q14990	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	ODF1	Q14990	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	ODF1	Q14990	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	ODF1	Q14990	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	ODF1	Q14990	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	ODF1	Q14990	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	ODF1	Q14990	KRT86	Homo sapiens	O43790	Y2H Prey Pooling	32296183
Intra	ODF1	Q14990	KRT86	Homo sapiens	O43790	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neuronopathy, Distal Hereditary Motor, Type Iic	HMN2C Hmn Iic Dhmn2c Distal Hereditary Motor Neuronopathy Type 2c Distal Hereditary Motor Neuropathy Type Iic Neuronopathy, Distal Hereditary Motor, Type 2c Neuropathy, Distal Hereditary Motor, Type Iic Neuronopathy, Distal Hereditary Motor, 2c Dhmn Iic Neuropathy, Motor, Distal, Hereditary, Type 2c
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Infertility
Spermatogenic Failure 16	SPGF16 Acephalic Spermatozoa Syndrome Spermatozoa, Acephalic
Male Infertility Due To Acephalic Spermatozoa	Acephalic Spermatozoa Syndrome
Distal Hereditary Motor Neuronopathy Type 2	Distal Hereditary Motor Neuropathy, Type Ii Distal Hereditary Motor Neuropathy Type 2 Distal Hereditary Motor Neuropathy Type Ii Hmn Ii Hmn2 Distal Hereditary Motor Neuronopathy, Type Ii Distal Spinal Muscular Atrophy Type 2 Dhmn2 Dsma2 Neuropathy, Motor, Distal, Hereditary, Type Ii Spinal Muscular Atrophy, Jerash Type
Spermatogenic Failure 9	Male Infertility Due To Globozoospermia SPGF9 Male Infertility Due To Round-Headed Spermatozoa Globozoospermia, Complete Globozoospermia, Total Globozoospermia Globozoospermia Syndrome Round-Headed Sperm Syndrome Globozoospermia Complete Globozoospermia Total
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09751	ODF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ODF1	RGD	RGD:3228
Bos taurus	ODF1	VGNC	VGNC:32400
Mus musculus	ODF1	MGD	MGI:97424
Macaca mulatta	ODF1	VGNC	VGNC:75579
Canis familiaris	ODF1	VGNC	VGNC:44098
Others	ODF1	NCBI