Phthalocyanine
Based on 1 Customer Validation
Phthalocyanine is a type of pigment and Photosensitizer. Upon irradiation, Phthalocyanine generates ROS or converts light energy into heat, inducing oxidative damage, cytotoxicity, and photodynamic killing of bacterial biofilms. Phthalocyanine produces chemiluminescence when oxidized. It can be used in studies related to cancer, bacterial infections, and photodynamic approaches.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 574-93-6
- Formula: C32H18N8
- Molecular Weight:514.54
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Phthalocyanine exhibits photodynamic cytotoxicity in unspecified cancer cells, with a light IC50 of 0.55 μM, a singlet oxygen quantum yield of 0.57, and extremely low dark cytotoxicity (dark IC50 >100 μM)[1].
Phthalocyanine exerts photodynamic cytotoxicity against HUVEC, breast cancer cell lines MCF-7 and MDA-MB-231, with IC50 values of 45.6 μM, 69.1 μM and 89.3 μM under light exposure[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 574-93-6
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Appearance Solid
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Molecular Weight 514.54
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Formula C32H18N8
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Color Dark purple to black
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SMILES
[H]N1C2=C3C=CC=CC3=C1/N=C4C5=C(C(/N=C6C7=C(/C(N/6[H])=N/C8=N/C(C9=C8C=CC=C9)=N\2)C=CC=C7)=N/4)C=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
Acetone : < 1 mg/mL (insoluble)
DMF : < 1 mg/mL (insoluble)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Rennie CC, et al. Targeted cancer phototherapy using phthalocyanine-anticancer drug conjugates. Dalton transactions (Cambridge, England : 2003). 2022 Sep 13;51(35):13157-13175. [Content Brief]
[3]. Spesia MB, et al. Evolution of Phthalocyanine Structures as Photodynamic Agents for Bacteria Inactivation. Chem Rec. 2022 Apr;22(4):e202100292. [Content Brief]
[4]. Jiang Z, et al. Pharmaceutical development, composition and quantitative analysis of phthalocyanine as the photosensitizer for cancer photodynamic therapy. J Pharm Biomed Anal. 2014 Jan;87:98-104. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phthalocyanine Related Classifications
HY-121310 Related Classifications
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- Phthalocyanine
- 574-93-6
- Bacterial
- Photosensitizer
- Reactive Oxygen Species (ROS)
- Biochemical Assay Reagents
- E. coli
- S. aureus
- S. mitis
- MDA-MB-231 human breast adenocarcinoma cells
- P. aeruginosa
- E. seriolicida
- HUVECs
- HepG2 human hepatocellular carcinoma cells
- MCF-7 human breast adenocarcinoma cells
- EMRSA
- Inhibitor
- inhibitor
- inhibit