2. Membrane Transporter/Ion Channel
    Neuronal Signaling
  3. GABA Receptor
  4. SJM-3

SJM-3 

Cat. No.: HY-131941
Handling Instructions

SJM-3 is a positive allosteric modulator of different isoforms of the GABAA receptor. SJM-3 binds at the high-affinity benzodiazepine binding site at the α+/γ- subunit interface.

For research use only. We do not sell to patients.

SJM-3 Chemical Structure

SJM-3 Chemical Structure

CAS No. : 1234977-97-9

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Description

SJM-3 is a positive allosteric modulator of different isoforms of the GABAA receptor. SJM-3 binds at the high-affinity benzodiazepine binding site at the α+/γ- subunit interface[1].

IC50 & Target

GABAA receptor[1]
In Vitro

SJM-3 binds at the high-affinity benzodiazepine binding site at theα+/γ- subunit interface but effects its action through another site presumably located within the transmembrane domain. The binding affinity of SJM-3 at wild type receptors is determined by displacement of [3H]-Flunitrazepam and [3H]-Ro15-1788 and indicates a Ki of SJM-3 amounting to 218±70 nM and 242±38 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

354.40

Formula

C18H15FN4OS
CAS No.
SMILES

CC(N1C(C2=CSC(C3=CN=CC=N3)=N2)=O)CCC4=C1C=CC(F)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

SJM-31234977-97-9SJM3SJM 3GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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