2. Apoptosis
  3. Apoptosis
  4. Taccalonolide E

Taccalonolide E is a microtubule stabilizer and induces cancer cell apoptosis.

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Taccalonolide E Chemical Structure

Taccalonolide E Chemical Structure

CAS No. : 134954-57-7

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Taccalonolide E Related Antibodies

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Description

Taccalonolide E is a microtubule stabilizer and induces cancer cell apoptosis.

In Vitro

Taccalonolide E (5 or 10 μM; 18 h) causes an increased density of cellular microtubules in interphase cells and the formation of thick bundles of microtubules in A-10 cells[1].
Taccalonolide E (1 or 5 μM; 18 h) causes the appearance of abnormal multipolar mitotic spindles in A-10 and HeLa cells[1].
Taccalonolide E (5 μM; 6-24 h) arrests cell cycle at G2-M phase[1].
Taccalonolide E (0.5-5 μM; 18 h) initiates micronucleation in interphase A-10 cells[1].
Taccalonolide E (48 h) inhibits cancer cell proliferation[1].
Taccalonolide E (10 μM; 1 h) causes polymerization of tubulin in MDA-MB-435 cells[1].
Taccalonolide E (5 μM; 4-30 h) initiates Bcl-2 phosphorylation, MAPK activation, and apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Taccalonolide E Related Antibodies

Cell Cycle Analysis[1]

Cell Line: MDA-MB-435 cells
Concentration: 5 μM
Incubation Time: 6, 12, 18, or 24 h
Result: Caused cells to accumulate in the G2-M phase of the cell cycle.

Cell Proliferation Assay[1]

Cell Line: SK-OV-3, MDA-MB-435, NCI/ADR, 1 A9, PTX 10, PTX 22 and 1A9/A8 cells
Concentration:
Incubation Time: 48 h
Result: Inhibited the proliferation with IC50s of 0.99 ± 0.08, 0.78 ± 0.17, 21.1 ± 0.46, 0.34 ± 0.04, 1.64 ± 0.25, 4.01 ± 0.20 and 1.42 ± 0.30 μM against SK-OV-3, MDA-MB-435, NCI/ADR, 1 A9, PTX 10, PTX 22 and 1A9/A8 cells, respectively.

Western Blot Analysis[1]

Cell Line: MDA-MB-435 cells
Concentration: 5 μM
Incubation Time: 4, 6, 12, 24, or 30 h
Result: Activated ERK1/2 and increased PARP cleavage.
Molecular Weight

644.71

Formula

C34H44O12
CAS No.
SMILES

CC(O[C@H]1[C@]2([H])[C@@]([C@@H](C=C3[C@@]2([C@](O)(C(O3)=O)C)C)C)([H])[C@@]4([C@]1([H])[C@@]5([H])[C@]([C@]6([C@H]([C@]7([H])[C@](O7)([H])C[C@]6([H])C([C@@H]5O)=O)OC(C)=O)C)([H])C[C@@H]4OC(C)=O)C)=O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Taccalonolide E Related Classifications

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Keywords:

Taccalonolide E134954-57-7ApoptosisA-10Bcl-2 phosphorylationMAPKMDA-MB-435Inhibitorinhibitorinhibit

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