Tembotrione

Cat. No.: HY-137910 Purity: 99.41%: Data Sheet
COA

SDS
Handling Instructions
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Tembotrione is a herbicide belonging to the HPPD (dioxygenase) inhibitor class with crop selectivity. Tembotrione effectively controls a variety of weeds including broadleaf and gramineous species by disrupting carotenoid synthesis, which leads to chlorophyll degradation and leaf whitening. Mixing Tembotrione with isoxaflutole or adding surfactants optimizes its efficacy and reduces phytotoxicity, with no residual impact on subsequent cruciferous crops, thus helping to increase maize grain yield. The activity of Tembotrione decreases under drought conditions, and under specific conditions (such as double-dose treatment), it may cause reversible yellowing and even yield reduction in crops such as poppy.

For research use only. We do not sell to patients.

Tembotrione Chemical Structure

CAS No. : 335104-84-2

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
Free Sample (0.1 - 0.2 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Other Forms of Tembotrione:

Tembotrione (Standard) Get quote

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Description

In Vivo

Tembotrione (88-176 g a.i. ha^-1; post-emergence foliar spray; single/split application) provides no significant weed control at a single 88 g a.i. ha^-1 dose in infested alkaloid poppy fields, while a split 176 g a.i. ha^-1 dose or a single 88 g a.i. ha^-1 dose following mesotrione application provides significant control of total weeds, Chenopodium album, and Polygonum aviculare (with additional control of Fallopia convolvulus dry weight in wetter conditions), but no control of Papaver rhoeas; all tembotrione doses cause transient, reversible yellowish foliar discoloration in poppy^[1].
Tembotrione (120 g/ha; post-emergence spray; 15-20 DAS; with 1000 mL/ha surfactant) provides the most effective control of mixed grassy (including Bracharia ramosa) and non-grassy weeds in maize, resulting in maximum grain yields of 5333 kg/ha (2009) and 5483 kg/ha (2010) with no residual phytotoxicity to a succeeding mustard crop^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Botond^[1]
Dosage:	88 g a.i. ha^-1 (single application); 176 g a.i. ha^-1 (split dose); 88 g a.i. ha^-1 (post mesotrione application)
Administration:	post-emergence foliar spray; single application (88 g a.i. ha^-1 single/split first dose); split application (176 g a.i. ha^-1: POST 1 and POST 2); single application (88 g a.i. ha^-1 POST 2, post mesotrione)
Result:	Failed to significantly reduce total weed count or dry weight in 2012 or 2013; did not significantly reduce Chenopodium album, Fallopia convolvulus, Papaver rhoeas, or Polygonum aviculare count or dry weight in either year. Caused transient yellowish discoloration (10-20% of foliage) 7-14 days after application, which resolved by 21 days post-treatment. Significantly reduced total weed count in 2012 and 2013, and total weed dry weight in 2012 and 2013; significantly reduced Chenopodium album count and dry weight in both years, and Polygonum aviculare count and dry weight in both years; did not significantly reduce Fallopia convolvulus or Papaver rhoeas count or dry weight in either year. Caused transient yellowish foliar discoloration (10-20% of foliage) 7-14 days after application, which resolved by 21 days post-treatment.

Molecular Weight

440.82

Formula

C₁₇H₁₆ClF₃O₆S

CAS No.

335104-84-2

Appearance

Solid

Color

White to light yellow

SMILES

O=C1C(C(C2=CC=C(S(=O)(C)=O)C(COCC(F)(F)F)=C2Cl)=O)C(CCC1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (226.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2685 mL	11.3425 mL	22.6850 mL
5 mM	0.4537 mL	2.2685 mL	4.5370 mL
10 mM	0.2268 mL	1.1342 mL	2.2685 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.41%

Select Batch:

Data Sheet (276 KB) SDS (701 KB)

COA (250 KB) HNMR (323 KB) RP-HPLC (233 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Pinke G, et al. Use of mesotrione and tembotrione herbicides for post-emergence weed control in alkaloid poppy (Papaver somniferum)[J]. International Journal of Pest Management, 2014, 60(3): 187-195.

[2]. Singh V P, et al. Bioefficacy of tembotrione against mixed weed complex in maize[J]. Indian journal of weed Science, 2012, 44(1): 1-5.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2685 mL	11.3425 mL	22.6850 mL	56.7125 mL
	5 mM	0.4537 mL	2.2685 mL	4.5370 mL	11.3425 mL
	10 mM	0.2268 mL	1.1342 mL	2.2685 mL	5.6712 mL
	15 mM	0.1512 mL	0.7562 mL	1.5123 mL	3.7808 mL
	20 mM	0.1134 mL	0.5671 mL	1.1342 mL	2.8356 mL
	25 mM	0.0907 mL	0.4537 mL	0.9074 mL	2.2685 mL
	30 mM	0.0756 mL	0.3781 mL	0.7562 mL	1.8904 mL
	40 mM	0.0567 mL	0.2836 mL	0.5671 mL	1.4178 mL
	50 mM	0.0454 mL	0.2268 mL	0.4537 mL	1.1342 mL
	60 mM	0.0378 mL	0.1890 mL	0.3781 mL	0.9452 mL
	80 mM	0.0284 mL	0.1418 mL	0.2836 mL	0.7089 mL
	100 mM	0.0227 mL	0.1134 mL	0.2268 mL	0.5671 mL

Tembotrione Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tembotrione335104-84-2Environmental PollutantsHPPDHerbicideEnvironmental Contaminants4-Hydroxyphenylpyruvate dioxygenaseChenopodium albumFallopia convolvulusmaizemesotrione4-hydroxyphenolpyruvate dioxygenasePapaver somniferummustard cropsisoxadifen-ethylPolygonum aviculareInhibitorinhibitorinhibit

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Tembotrione

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