Deferoxamine-DBCO
Based on 1 Customer Validation
Deferoxamine-DBCO is a bifunctional chelating agent. Deferoxamine-DBCO efficiently chelates with radioactive metals (such as 89Zr) through the DFO structure to achieve radiolabeling. Deferoxamine-DBCO undergoes a metal-free Huisgen cycloaddition reaction with azide-containing biomolecules (such as siRNA, monoclonal antibodies) under bioorthogonal conditions through the DBCO structure to achieve targeted coupling. Deferoxamine-DBCO has efficient metal chelating ability and specific bioorthogonal reaction activity. Deferoxamine-DBCO can be used for targeted radioactive imaging studies of tumors.
For research use only. We do not sell to patients.
- Purity: 89.08%
- CAS No.: 2359695-48-8
- Formula: C44H61N7O10
- Molecular Weight:848.00
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Radionuclide-Drug Conjugates (RDCs) Isoforms
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Biological Activity
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RDC Bifunctional Chelator |
Chemical Information
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CAS No. 2359695-48-8
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Appearance Solid
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Molecular Weight 848.00
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Formula C44H61N7O10
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Color White to yellow
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SMILES
CC(N(CCCCCNC(CCC(N(CCCCCNC(CCC(N(CCCCCNC(CCC(N1CC2=C(C=CC=C2)C#CC3=C1C=CC=C3)=O)=O)O)=O)=O)O)=O)=O)O)=O
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Synonyms
DFO-DBCO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (117.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Sales ZS, et al. Practical syntheses of DOTAGA-DBCO and DFO-DBCO, strained alkyne pre-cursors to radioimmunoconjugates for targeted alpha therapy. Bioorg Med Chem. 2022 Nov 1;73:117010. [Content Brief]
[2]. Hofstraat SRJ, et al. Nature-inspired platform nanotechnology for RNA delivery to myeloid cells and their bone marrow progenitors. Nat Nanotechnol. 2025 Apr;20(4):532-542. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1792 mL | 5.8962 mL | 11.7925 mL | 29.4811 mL |
| 5 mM | 0.2358 mL | 1.1792 mL | 2.3585 mL | 5.8962 mL | |
| 10 mM | 0.1179 mL | 0.5896 mL | 1.1792 mL | 2.9481 mL | |
| 15 mM | 0.0786 mL | 0.3931 mL | 0.7862 mL | 1.9654 mL | |
| 20 mM | 0.0590 mL | 0.2948 mL | 0.5896 mL | 1.4741 mL | |
| 25 mM | 0.0472 mL | 0.2358 mL | 0.4717 mL | 1.1792 mL | |
| 30 mM | 0.0393 mL | 0.1965 mL | 0.3931 mL | 0.9827 mL | |
| 40 mM | 0.0295 mL | 0.1474 mL | 0.2948 mL | 0.7370 mL | |
| 50 mM | 0.0236 mL | 0.1179 mL | 0.2358 mL | 0.5896 mL | |
| 60 mM | 0.0197 mL | 0.0983 mL | 0.1965 mL | 0.4914 mL | |
| 80 mM | 0.0147 mL | 0.0737 mL | 0.1474 mL | 0.3685 mL | |
| 100 mM | 0.0118 mL | 0.0590 mL | 0.1179 mL | 0.2948 mL |
Deferoxamine-DBCO Related Classifications
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