DENR - density regulated re-initiation and release factor Gene

Also Known as DRP; DRP1; SMAP-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8562

About DENR

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:122,752,824-122,771,064 (from NCBI)

This gene has 4 transcripts (splice variants) and 230 orthologues. Ubiquitous expression in thyroid (RPKM 16.4), lymph node (RPKM 16.3) and 25 other tissues.

Summary

This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and Plants. [provided by RefSeq, Jul 2008]

DENR Products (1)

mRNA	Protein	Name
NM_003677.5	NP_003668.2	density-regulated protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in IRES-dependent viral translational initiation	IDA IDA: Inferred from direct assay	20713520	GOA
involved in formation of translation preinitiation complex	IDA IDA: Inferred from direct assay	20713520	GOA
involved in ribosome disassembly	IDA IDA: Inferred from direct assay	20713520	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	16982740	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DENR Protein Structure

SUI1

0
100
198 a.a.

Protein Preferred Names	Protein Names
density-regulated protein	smooth muscle cell associated protein-3

DENR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DENR	O43583	MARCHF5	Homo sapiens	Q9NX47	Anti Tag CoIP	16874301
Intra	DENR	O43583	MARCHF5	Homo sapiens	Q9NX47	Anti Tag CoIP	16936636
Intra	DENR	O43583	NELFB	Homo sapiens	Q8WX92	TAP	20195357
Intra	DENR	O43583	MCTS1	Homo sapiens	Q9ULC4	Validated Y2H	32296183
Intra	DENR	O43583	MCTS1	Homo sapiens	Q9ULC4	Y2H	21516116
Intra	DENR	O43583	MCTS1	Homo sapiens	Q9ULC4	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DENR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72172	DENR Protein, Human (His-SUMO)	O43583 (A2-K198)	≥ 90%, as determined by reducing SDS-PAGE.

DENR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810811	DENR Antibody (YA10054)	WB, IHC-P, ICC/IF, FC	Human

Related Diseases

Diseases	Alias
Capillary Malformations, Congenital	Familial Multiple Nevi Flammei Nevi Flammei, Familial Multiple CMC Port-Wine Stain Capillary Malformations Cmal Familial Multiple Port-Wine Stains Capillary Malformation Capillary Malformations, Congenital, 1, Somatic, Mosaic Congenital Capillary Malformations Port-Wine Stain Familial Multiple Hereditary Capillary Malformations Capillary Malformations, Hereditary Capillary Malformations, Congenital, Type 1, Somatic, Mosaic Strawberry Nevus Of Skin Naevus Flammeus
Optic Nerve Disease	Optic Neuropathy Disorder Of The Second Nerve Optic Nerve Disorder Optic Nerve Abnormality Of The Optic Nerve Optic Nerve Disorders Neuropathy, Optic Disorder Of The Optic Nerve
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03692	DENR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20267	Denr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26775	Denr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DENR	MGD	MGI:1915434
Canis familiaris	DENR	VGNC	VGNC:52927
Macaca mulatta	DENR	VGNC	VGNC:108337
Rattus norvegicus	DENR	RGD	RGD:1584200
Felis catus	DENR	VGNC	VGNC:80435
Others	DENR	NCBI