TXA6101 

TXA6101 is a bacterial protein FtsZ (filamentous temperature-sensitive protein Z) inhibitor that inhibits bacterial division. TXA6101 has antimicrobial activity against MRSA isolates expressing either the G193D or G196S mutant FtsZ with the MIC value of 1 μg/mL, retains significant activity against the TXA707-resistant FtsZ mutant. TXA6101 can be used as a potential method against Gram-negative bacterial infections^[1][2].

TXA6101 has antibacterial activity against MRSA with the MIC value of 0.125 μg/mL while TXA707 with the MIC value of 1 μg/mL^[2].
TXY6129 inhibits the polymerization of Escherichia coli FtsZ in a concentration-dependent manner and induces morphological changes in Escherichia coli and Klebsiella pneumoniae^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

477.18

C₁₈H₁₀BrF₅N₂O₃

1459695-66-9

O=C(N)C1=C(F)C=CC(OCC2=NC(C3=CC=C(C(F)(F)F)C=C3)=C(Br)O2)=C1F

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Andrea Casiraghi, et al. Targeting Bacterial Cell Division: A Binding Site-Centered Approach to the Most Promising Inhibitors of the Essential Protein FtsZ. Antibiotics (Basel). 2020 Feb 7;9(2):69.  [Content Brief]

  [2]. Junso Fujita, et al. Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ. ACS Chem Biol. 2017 Jul 21;12(7):1947-1955.  [Content Brief]

  [3]. Jesus D Rosado-Lugo, et al. Evaluation of 2,6-difluoro-3-(oxazol-2-ylmethoxy)benzamide chemotypes as Gram-negative FtsZ inhibitors. J Antibiot (Tokyo). 2022 Jul;75(7):385-395.  [Content Brief]