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United States

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Cat. No.: HY-175909

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BTK ligand-18

BTK ligand-18 is a BTK ligand, which can be used for the synthesis of PROTACs, such as PROTAC BTK Degrader-9 (HY-162280).

For research use only. We do not sell to patients.

Formula: C₂₂H₂₄FN₉O
Molecular Weight:449.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BTK ligand-18 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

BTK ligand-18 is a BTK ligand, which can be used for the synthesis of PROTACs, such as PROTAC BTK Degrader-9 (HY-162280)^[1].

Chemical Information

Molecular Weight 449.48
Formula C₂₂H₂₄FN₉O
SMILES

CC1=CC(C2=NC(NC3=CNN=C3)=NC=C2F)=CC=C1CNC(C4=CN(C(C)(C)C)N=N4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Huang J, et al. Discovery of Novel Potent and Fast BTK PROTACs for the Treatment of Osteoclasts-Related Inflammatory Diseases. J Med Chem. 2024 Feb 22;67(4):2438-2465. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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