CRKL - CRK like proto-oncogene, adaptor protein Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1399

About CRKL

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:20,917,407-20,953,747 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 22.4), bone marrow (RPKM 22.0) and 25 other tissues.

Summary

This gene encodes a protein kinase containing SH2 and SH3 (Src homology) domains which has been shown to activate the Ras and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the Bcr-Abl tyrosine kinase, plays a role in fibroblast transformation by Bcr-Abl, and may be oncogenic.[provided by RefSeq, Jan 2009]

CRKL Products (1)

mRNA	Protein	Name
NM_005207.4	NP_005198.1	crk-like protein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	29581031	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17161365	GOA
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	20624904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8626543	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to transforming growth factor beta stimulus	IMP IMP: Inferred from mutant phenotype	23959425	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23959425	GOA
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	23959425	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	23959425	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	25540073	GOA
involved in positive regulation of glial cell migration	IMP IMP: Inferred from mutant phenotype	23959425	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	23959425	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	19004829	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRKL Protein Structure

SH2

SH3_1

SH3_2

0
100
200
303 a.a.

Protein Preferred Names	Protein Names
crk-like protein	v-crk avian sarcoma virus CT10 oncogene homolog-like

CRKL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CRKL	P46109	FLT1	Homo sapiens	P17948	Anti Tag CoIP	23397142
Intra	CRKL	P46109	FLT1	Homo sapiens	P17948	PLA	23397142
Cross	CRKL	P46109	Kcnma1	Mus musculus	Q08460	Anti Bait CoIP	17065230
Intra	CRKL	P46109	BLK	Homo sapiens	P51451	Validated Y2H	32296183
Intra	CRKL	P46109	PDGFRA	Homo sapiens	P16234	CoIP	9546424
Intra	CRKL	P46109	PDGFRA	Homo sapiens	P16234	PLA	25241761
Intra	CRKL	P46109	PDGFRA	Homo sapiens	P16234	Enzymatic Study	9546424
Intra	CRKL	P46109	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	CRKL	P46109	PSMC6	Homo sapiens	P62333	Validated Y2H	32296183
Intra	CRKL	P46109	ABL1	Homo sapiens	P00519	Anti Tag CoIP	33961781
Intra	CRKL	P46109	ABL1	Homo sapiens	P00519	Anti Bait CoIP	16443220
Intra	CRKL	P46109	ABL1	Homo sapiens	P00519	Pull Down	16443220
Intra	CRKL	P46109	GAB1	Homo sapiens	Q13480	PLA	25241761
Intra	CRKL	P46109	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	CRKL	P46109	GAB1	Homo sapiens	Q13480	PLA	23397142
Intra	CRKL	P46109	CBL	Homo sapiens	P22681	Anti Tag CoIP	33961781
Intra	CRKL	P46109	CBL	Homo sapiens	P22681	CoIP	8662998
Intra	CRKL	P46109	CBL	Homo sapiens	P22681	Y2H Array	25814554
Intra	CRKL	P46109	CBL	Homo sapiens	P22681	Anti Bait CoIP	16982329
Intra	CRKL	P46109	ITGB1	Homo sapiens	P05556	Anti Bait CoIP	19168626
Intra	CRKL	P46109	USP53	Homo sapiens	Q70EK8	Validated Y2H	32296183
Intra	CRKL	P46109	CBLB	Homo sapiens	Q13191	CoIP	10022120
Intra	CRKL	P46109	CBLB	Homo sapiens	Q13191	Validated Y2H	25814554
Intra	CRKL	P46109	DCBLD2	Homo sapiens	Q96PD2	Pull Down	23770091
Intra	CRKL	P46109	MAP4K1	Homo sapiens	Q92918	Pull Down	9788432
Intra	CRKL	P46109	MAP4K1	Homo sapiens	Q92918	CoIP	9788432
Intra	CRKL	P46109	CRKL	Homo sapiens	P46109	X-Ray Diffraction	17161365
Intra	CRKL	P46109	CRKL	Homo sapiens	P46109	Comigration in SDS	17161365
Intra	CRKL	P46109	RAPGEF1	Homo sapiens	Q13905	Anti Tag CoIP	26496610
Intra	CRKL	P46109	RAPGEF1	Homo sapiens	Q13905	Pull Down	16443220
Cross	CRKL	P46109	Kidins220	Rattus norvegicus	Q9EQG6	Pull Down	16284401

Cross: Cross-species interaction Intra: Intraspecies interaction

CRKL Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810591	Phospho-CrkL (Tyr207) Antibody (YA9855)	WB	Human, Mouse, Rat
HY-P82832	CrkL Antibody (YA2577)	WB, IHC-P, ICC/IF	Human
HY-P85109	CrkL Antibody (YA4801)	WB, FC, ELISA	Human

Related Diseases

Diseases	Alias
Chromosome 22q11.2 Deletion Syndrome, Distal	22q11.2 Deletion Syndrome Autosomal Dominant Opitz G/Bbb Syndrome Catch22 Cayler Cardiofacial Syndrome Conotruncal Anomaly Face Syndrome Digeorge Syndrome Sedlackova Syndrome Shprintzen Syndrome Velocardiofacial Syndrome 22q11.2 Distal Deletion Syndrome Distal 22q11.2 Microdeletion Syndrome 22q11.2ds Vcfs Velo-Cardio-Facial Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Chromosome 22q11.2 Deletion Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Deletion 22q11.2 Syndrome 22q11ds Catch 22 Digeorge Sequence Microdeletion 22q11.2 Monosomy 22q11 Takao Syndrome Distal Del(22)(Q11.2) Distal Monosomy 22q11.2 Catch 22 Syndrome Chromosome Deletion Syndrome 22q11.2, Distal
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Digeorge Syndrome	Chromosome 22q11.2 Deletion Syndrome DGS Hypoplasia Of Thymus And Parathyroids Third And Fourth Pharyngeal Pouch Syndrome 22q11.2 Deletion Syndrome Digeorge Sequence Digeorge'S Syndrome Pharyngeal Pouch Syndrome Di-George Syndrome Shprintzen Syndrome
T-Cell Immunodeficiency With Thymic Aplasia	Nezelof Syndrome T-Lymphocyte Deficiency TIDTA Immune Defect Due To Absence Of Thymus Thymic Aplasia Nezelof'S Syndrome Thymic Dysplasia With Normal Immunoglobulins Thymic Aplasia Syndrome T-Lymphocyte Immunodeficiency
Bladder Exstrophy-Epispadias-Cloacal Exstrophy Complex	Exstrophy-Epispadias Complex Bladder Exstrophy-Epispadias-Cloacal Extrophy Complex Beec Eec Exstrophy Of The Bladder Bladder Exstrophy Bladder Exstrophy And Epispadias Complex
Velocardiofacial Syndrome	Shprintzen Syndrome VCFS Chromosome 22q11.2 Deletion Syndrome Vcf Syndrome Shprintzen Vcf Syndrome Vcf-Velocardiofacial Syndrome Velo-Cardio-Facial Syndrome Digeorge Syndrome 22q11 Deletion Syndrome Conotruncal Anomaly Face Syndrome
Chromosome 22q11.2 Duplication Syndrome	Chromosome 22q11.2 Microduplication Syndrome 22q11.2 Microduplication Syndrome 22q11.2 Duplication Syndrome Duplication 22q11.2 Trisomy 22q11.2 22q11.2 Duplication Dup(22)(Q11)
Chromosomal Deletion Syndrome
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Double Outlet Right Ventricle	Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect Taussig-Bing Syndrome Dextrotransposition Of Aorta Taussig-Bing Syndrome Or Defect Dorv Dorv With Subpulmonary Vsd Dorv-Tga Double Outlet Right Ventricle With Transposition Of The Great Arteries Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type Taussig-Bing Heart Taussig-Bing Malformation Taussig-Bing Complex Taussig-Bing Defect Taussig-Bing Double Outlet Right Ventricle With Remote Ventricular Septal Defect Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect Double Outlet Right Ventricle With Non-Committed Interventricular Communication Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis
Tetralogy Of Fallot	TOF Fallot Tetralogy Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle Tetrad Of Fallot Fallot Tetrad Fallot Disease Fallot Complex Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle Interventricular Septal Defect, In Tetralogy Of Fallot Ventricular Septal Defect With Obstructed Right Ventricular Outflow Tof - [Tetralogy Of Fallot] Pulmonary Atresia With Ventricular Septal Defect [Fallot Type] Pulmonary Atresia, Ventricular Septal Defect And Mapcas Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
Chromosome 1p36 Deletion Syndrome	1p36 Deletion Syndrome Deletion 1p36 Monosomy 1p36 Subtelomeric 1p36 Deletion Monosomy 1p36 Syndrome Distal Monosomy 1p36 Del(1)(P36) Deletion 1pter Monosomy 1pter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-184100S	Relcobatinib	Inhibitor	/	Unkown
HY-125090	PHA-680626		/	Unkown
HY-178382	BRAFV600E/ABL2-IN-1		/	Unkown
HY-180969	SIAIS056	Degrader	/	Unkown
HY-181726	BRAFV600E/ABL2-IN-2		/	Unkown
HY-RS03185	CRKL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-164469	CHMFL-48	Inhibitor	/	Unkown
HY-RS19315	Crkl Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25806	Crkl Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CRKL	VGNC	VGNC:53897
Mus musculus	CRKL	MGD	MGI:104686
Rattus norvegicus	CRKL	RGD	RGD:1308531
Felis catus	CRKL	VGNC	VGNC:61182
Canis familiaris	CRKL	VGNC	VGNC:39619
Others	CRKL	NCBI