Kidins220 - kinase D-interacting substrate 220 Gene

Also Known as ARMS

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116478

Summary

Enables PDZ domain binding activity; protein kinase binding activity; and protein kinase regulator activity. Involved in nerve growth factor signaling pathway and positive regulation of neuron projection development. Located in late endosome. Part of protein-containing complex. Orthologous to human KIDINS220 (kinase D interacting substrate 220). [provided by Alliance of Genome Resources, Apr 2022]

Kidins220 Products (1)

mRNA Protein Name
NM_053795.2 NP_446247.2 kinase D-interacting substrate of 220 kDa

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IDA
IDA: Inferred from direct assay
17724123 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16284401 RGD
enables protein kinase binding IDA
IDA: Inferred from direct assay
11150334 RGD
enables protein kinase regulator activity IDA
IDA: Inferred from direct assay
11150334 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to nerve growth factor stimulus IDA
IDA: Inferred from direct assay
17724123 RGD
involved in nerve growth factor signaling pathway IDA
IDA: Inferred from direct assay
17724123 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
17724123 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20547223 RGD
located in late endosome IDA
IDA: Inferred from direct assay
17724123 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
20547223 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
17724123 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kinase D-interacting substrate of 220 kDa

  • ankyrin repeat-rich membrane-spanning protein

  • kinase D-interacting substance 220

  • kinase D-interacting substance of 220 kDa

Kidins220 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Kidins220 Q9EQG6 CRKL Homo sapiens P46109
Pull Down
16284401
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07254 KIDINS220 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kidins220 NCBI NCBI:57498